Enhancers and chromatin looping

para 3

Enhancers and chromatin looping

1

1.      Tfs don’t act in isolation

1.      Tfs don’t act in isolation topics

mech

example

2

enhancers

enhancers topics

Def

Location

Function

3

chromaitn looping

chromatin looping topics

mech

4

3d architechture

3d architechture topics

Mechanisms

Examples

function

TFs do not act in isolation; mech

they function by binding to regulatory elements,

TFs do not act in isolation; example

enhancers.

Enhancers def

predominant functional elements

enhancers

location

in the non-coding genome,

enhancers function

capable of activating transcription independent of their distance or orientation from a target gene.

chromatin looping mechanism

active enhancers are bound by TFs and brought into physical proximity with target promoters through chromatin looping.

3d architecture

mech

mediated by protein complexes

3d architecture

examples

cohesin and Mediator,

3d architecture

function

facilitate the molecular crosstalk required for precise gene activation