#8 Antimicrobial Drugs-Drug Resistance

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4 Terms

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blasting same drug on bacteria

  • → gain resistance

  • Penicillin resistance + Sulfa Drug resistance are commonly resisted because its been taken for so long

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Intrinsic v.s Acquired Resistance

  • intrinsic: natural selection (survival of the fittest)

  • acquired: picked up the ability to do horizontal gene transfer (from DNA)

    • Staph+Strep are good at this

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Microbe may “resist” antimicrobials by…

  • Inactivation Drug (special enzymes)

    • Beta Lactamase

  • Altering uptake receptors (surface)

    • MRSA does this

  • “pumps” simply EXPEL drug

    • within cytoplasm

    • think ribosome inhibitors

  • “Re-Routing” of Metabolism

  • etc.

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