adaptive immunity review

What are the characteristics of the adaptive immune system

• adaptive immunity takes time to develop

• adaptive immunity improves with time

• memory

• T and B lymphocytes

Common palpable lymph nodes

• submandibular

• prescapular

• axillary

• inguinal

• Popliteal

T vs B cells

• both originate from stem cells in bone marrow

• immature T lymphocytes migrate into thymus

• immature B lymphocytes migrate to the gut or stay in bone marrow

• when mature they migrate into lymph nodes and other lymphoid tissues

Where are T cells and what are they used for

• thymus

• two stage process-must interact with MCH, must not be activated by self antigens

• 98% of T cells die in thymus either because they cannot bing to MHC or are activated by normal antigens

What does MHC stand for

Major histocompatibility complex

what are the 3 major functions of MHC receptors

• MCH I - act as a unique body identifier

• MCH II- are mainly found on immune cells

• MCH III-are PRR, signalling molecules and complement components

major classes of antibody and how many binding sites does each have

• IgA : 4

• IgM : 10

• IgG : 2

• IgE : 2

What Ig class is first produced in humoral immunity

IgM

What Ig presents largest in circulation largest in circulation

IgG

what Ig is produces in the greatest amount in a day

IgA

which Ig class binds to mast cells

IgE

Which cells produce Ig

Ig is produced by B cells and plasma cells

what are mechanisms by which Ig can neutralize pathogens

• angulation

• neutralization

• opsonization for phagocytosis

• Complement activation and opsonization or MAC

• antibody dependent cell cytotoxicity