cpje secrets - urology

Caution associated with α1 blockers

Syncope (due to orthostatic HTN after initial dose), dizziness and fatigue

What should you do with alpha blockers to prevent syncope?

Titrate

Cardura

Doxazosin

Hytrin

Terazosin

Minipress

Prazosin

Flomax

Tamsulosin

Uroxatral

Alfuzosin

Rapaflo

Sildosin

Cardua dosing for HTN

16 mg QHS

Cardura dosing for BPH

8mg QHS

Hytrin dosing for HTN

max 20mg QHS

Hytrin dosing for BPH

10mg QHS

Minipress dosing for HTN

5 mg BID-TID

Flomax

Tamsulosin

Flomax dosing

0.4 mg QD 30 min after same meal each day

Uroxatral dosing

10 mg QD with same meal each day

Rapaflo dosing

8 mg QD with food

5alpha-reductase inhibitor pregnancy category

X

Pregnant women should not handle which medication used for BPH?

5alpha reductase inhibitors

5alpha reductase inhibitor SEs: sexual (decreased libido/semen, impotence), risk of prostate cancer

Avodart

Dutasteride

Avodart dosing

0.5 mg QD

Jalyn

Dutasteride/Tamsulosin

Proscar

Finasteride

Proscar dosing

5 mg QD

Propecia

Finasteride

Propecia dosing

1 mg QD

Common herbals for BPH

Saw palmetto, beta-sitosterol, pumpkin see

What foods or supplements contain beta-sitosterol?

Pumpkin seed, soy, red clover

Phosphodiesterase inhibitors are contraindicated with what other medications?

Nitrates

What happens if a patient on PDE5 inhibitors take nitrates?

Severe hypotension

Caution with PDE5s and alpha-blockers

dizziness, hypotension and orthostasis

PDE5 inhibitors cannot be used with what medications?

Itraconazole, riociguat, vericiguat

Caution with PDE5 inhibitors

priapism, sudden vision and hearing loss, color discrimination impairment, 3A4 substrates, nasal congestion, facial redness

Stendra

Avanafil

Levitra

Vardenafil

Staxyn

Vardenafil ODT

Viagra

Sildenafil for ED

Cialis

Tadalafil for ED

Stendra dosing

100 mg 15 min before sex with or without food

Staxyn dosing

10 mg an hour before sex on an empty stomach

Levitra dosing

10 mg an hour before sex on an empty stomach

Levitra dosing range

5 to 20 mg as a single dose (not more than once daily)

Levitra max daily dose

20 mg

Viagra dosing for elderly patients

25 mg an hour before sex on an empty stomach

Viagra dosing

50 mg an hour before sex on an empty stomach

Revatio

Sildenafil for PAH

Revatio dosing

20 mg TID

Cialis dosing

10 mg one hour before sex or 2.5-5mg QD with or without food

Which PDE5 inhibitor is approved for BPH?

Cialis

Adcirca

Tadalafil for PAH

Tadlic

Tadalafil oral suspension for PAH

Adcirca dosing for PAH

40 mg QD

Caverject

Alprostadil intracavernosal injection into the penis

Caverject auxiliary label

refrigerate

Prostacyclin

Epoprostenol

Flolan

Epoprostenol

Ventavis

Ilprost

Tracleer

Bosentan

Tyvaso

Treprostinil

Anticholinergic/Muscarinic receptor antagonists side effects

dry mouth, constipation, blurred vision, urinary retention, dizziness, drowsiness

Ditropan

Oxybutynin

Ditropan XL

Oxybutynin ER

Oxytrol TD

Oxybutynin Patch OTC

Gelnique

Oxybutynin 10%gel

Ditropan XL MDD

30mg

Oxytrol dosing

Twice a week

Detrol

Tolterodine

Detrol dosing

2 mg bid

Vesicare

Solifenacin

Vesicare dosing

10 mg QD

Enablex

Darifenacin

Enablex dosing

15 mg QD

Myrbetriq

Mirabegron

Myrbetriq dosing

25 mg QD

Toviaz

Fesoterodine

Toviaz dosing

8 mg QD

Sanctura

Trospium

Sanctura dosing

20 mg BID on empty stomach

Which PDE5 inhibitors should be taken on an empty stomach

Vardenafil and Sildenafil