-Statins

These flashcards cover key concepts related to statins, a class of antihyperlipidemic agents, including drug actions, brand and generic names, indications for use, side effects, and important interactions.

What is the drug category of statins?

Antihyperlipidemic.

What enzyme do statins inhibit to reduce cholesterol levels?

HMG-CoA reductase.

Name one brand and its generic equivalent from the statin class.

Crestor - rosuvastatin.

What are the indications for using statins?

Hyperlipidemia to lower LDL, reduce the risk of MI and angina, and reduce the risk of CAD.

What serious side effect is associated with statin use?

Rhabdomyolysis.

List two common side effects of statin medications.

Mild muscle pain/muscle cramps and headache.

constipation

n/v/d

What effect does grapefruit juice have on certain statins?

It increases levels of atorvastatin, lovastatin, and simvastatin, which may increase the risk of side effects.

What is the action of statins in terms of lipid levels?

They promote reduction of lipid levels in the blood.

What is the primary route of administration for statins?

Oral (PO).

What specific lipid levels do some antihyperlipidemic agents aim to lower?

Low-density lipoprotein (LDL) cholesterol.