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What other drug classes can be used to tx BPD
antidepressnats and antipsychotics
what drug interactions are there with lithium
it interacts with ACEs or loop diuretics
What do you need to monitor with lithium
Serum lithium levels, renal function and thyroid function
what are examples of SSRI
Celexa, Lexapro, Prozac, Paxil, Luvox, Zoloft
What are AE of venlafaxine
drowsiness, dizziness, HA, nightmares, N/V and stomach pain
What are AE of monoamine oxidase inhibitors
CNS Stimulation, orhtostatic hypotension, HTN crisis from dietary tyramine
what food interactions does MAOIs have
avocados, figs, meats that are fermented or smoked, fish, milk, cheese and beer/wine d/t their tyramine concentrations
When is antidepressant-induced suicide more prevalent?
in children, teens and adults younger than 25
What do patients need to know about SSRIs
they should not be stopped abruptly, d/c can result in rebound anxiety
if tx has lasted less than 8 weeks then d/c over 1-2 weeks is safe.
What patients are appropriate for MAOIs
atypical depression, those that have not responded to other antidepressants
What baseline data is needed to minimize the AE when prescribing SSRI or SNRIs
serum sodium in oldera dults and patients on diuretic therapy.
What baseline data is needed before staring tricyclic antidepressants
ECG
What baseline data is needed before starting MAOIs
BP
Medications used to tx panic disorders.
Paroxetine, sertraline, fluoxetine
Medications to manage social anxiety disorder
Zoloft, paroxetine - drug therapy takes 4 weeks to see effects.
SE of 1st gen antipsychotics
hypotension, medications can have sedative SE so caution when driving
SE of 2nd gen antipsychotics
Clozapine can cause life threatening agranulocytosis. use it for patients who have not responded to safer alternatives
Appropriate tx with trazadone
insomnia resulting from use of antidepressants that cause significant CNS stimulation
appropriate tx with zaleplon
Benzodiazepine like drug to assist with falling and staying asleep
appropriate tx with zolpidem
benzodiazepine like drug to assist with falling and staying asleep
appropriate tx with flurazepam
benzodiazepine for the long lasting effects
Example of Benzodiazepine
triazolam
example of benzodiazepine like drug
Lunesta, sonata, ambien
Examples of melatonin receptor agonists
Rozarem
Common issue with Kava
severe liver injury
common issue with ginkgo biloba
suppresses platelet aggregation and can increase risk of bleeding in patients receiving antiplatelet or anticoagulant drugs
issues with echinacea
can oppose the effects of immunosuppressant drugs, compromise drug therapy of TB, Cancer and HIV
Issues with St. John's Wort
interact adversely with many drugs: induction of cytochrome P450, induction of P-glycoprotein and intensification of serotonin effects
issues with ginger root
inhibit production of thromboxane by platelets can suppress platelet aggregation
issues with flaxseed
reduce absorption of convential medications should be taken 1 hour before or two hours after can cause bloating, gas, abd discomfort