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% of O2 carried in plasma
2%
% of oxygen bound for hemoglobin
98%
Fully Saturated RBC 4x O2 bound
Oxyhemoglobin (HbO2)
No O2 bound to RBC
Deoxyhemoglobin
Atmospheric pressure
760mmHg
Oxygen Composition/partial pressure
21% 160mmHg
Nitrogen composition/partial pressure
78% 0.3mmHg
CO2 composition/partial pressure
0.04% 590mmHg
H2O composition/Partial Pressure
0% 0mmHg
Alveolar Composition/partial pressure of oxygen
13.6% 160mmHg
Alveolar Composition/Partial Pressure of CO2
5.3% 40mmHg
Alveolar Composition/Partial Pressure of nitrogen
74.9% 569mmHg
Alveolar Composition/Partial Pressure of H2O
6.2% 47mmHg
Atrial Blood Gasses
ABGs assess the patient’s oxygenation at the tissue level
Normal Values PaO2
90-100 mmHg
Normal Values PaCO2
35-45 mmHg
Normal Values PaHCO3
22-29 mmHg
Normal pH Values
7.35-7.45 mmHg
Blood Values Arteries
PaO2 = 90-100 mmHg
PaCO2 = 40 mmHg
Blood Values Tissues
PtO2 = 40 mmHg
PtCO2 = 45mmHg
Blood Values Veins
PvO2 = 40 mmHg
PvCO2 = 45mmHg
Blood Values Alveoli
PaO2 = 110 mmHg
PaCO2 = 40 mmHg
Oxygen Saturation SpO2
Measure of Oxygenation at the tissue level measures the % of hemoglobin saturated with O2
How does a pulse oximeter work
2 infrared wavelengths are sent through arterial bed, a photodetector measures the amount of red light that passed through vs absorbed and records data on a plethysmograph
Issues with Pulse Oxyimetry
Affected by: movement, Anemia, Venous Pulsations, CO poisoning, Low perfusion, Nail polish, Edema, Ambient light
Normal SpO2
95%
Cyanosis SpO2
80%
O2 Administration
Titrate to 92-96%
O2 Administration COPD
Titrate to 88-92%
Situations that require High-Flow O2 regardless of SpO2 reading
CO/Cyanide poisoning, Upper Airway Burns, Scuba Diving Accidents, VSA’s and airway obstructions, Sickle Cell disease
HCO3 CO2 %
60%
Hemoglobin CO2 %
30%
CO2 % dissolved in plasma
10%
What compound collects the most CO2 out of the body
HCO3 Bicarbonate 60%
Cheoreceptors sense changes in
CO2, pH+, O2
Central Chemoreceptors
Neurons in the Medulla and Oblongata, most sensitive to pH + CO2
Peripheral Chemoreceptors
Neurons in Carotid bodies and Aortic Arch, most sensitive to changes in O2
End-Tidal CO2 (EtCO2)
The amount of CO2 at the end of expiration
Capnography
Waveform
Capnometry
Numerical value
Normal EtCO2
35-45 mmHg
Alkalosis EtCO2
< 35 mmHg hyperventilation
Acidosis
> 45mmHg Hypoventilation
EtCO2 Factors
CO2 Production
Blood Flow Back to Heart
Alveolar Ventilation
Phase 1
Respiratory Baseline (Dead Air)
Phase 2
Expiratory Upstroke (Beginning of Exhalation)
Phase 3
Expiratory plateau (exhalation)
Phase 0
Inhalation
EtCO2
Peak of expiratory plateau
Sudden Drop in EtCO2
Equipment Failure
Disconnection of ventilator
Choking
Gradual Drop in EtCO2
Hyperventilation
Cardiac Arrest
Sudden onset of hypotension
Sudden Rise in EtCO2
ROSC
Release of tourniquet
Increase in BP
Increase in Body Temp
Ventilation of previously unventilated lung
Gradual Rise in EtCO2
Hypoventilation (retaining CO2)
Shark Fin EtCO2
Bronchocontriction
Air Trapping
Indicates need for bronchodilators
EtCO2 for COPD/Asthmatic Patients
Maintain 50-60 mmHg
EtCO2 for Head Injuries
35-45 mmHg
EtCO2 for Herniation
30-35 mmHg
SA Node
Sino-Atrial Node sets the pace (fastest rate)
AV Node
Delays the signal so left atrium pumps after right atrium
Bundle of His
Signal Super-highway, sends signals to purkinje fibers and responisble for how narrow QRS
Purkinjie Fibers
Rapidly send signals through the ventricles
SA Node BPM
60-100 BPM
AV Node BPM
40-60 BPM
Perkinjie Fibers BPM
20-40 BPM
ECG
Electrocardiogram, records electrical activity of the heart
P-Wave
Atrial Depolarization
PR Interval
Impulse Travelling from SA-AV
QRS Complex
Ventricular Depolarization
T-Wave
Ventricular Re-polarization
P-wave interval
< 0.12s or < 3 squares
PR Interval
< 0.2s or 1 big Square
QRS Complex Interval
0.08s - 0.1s or 2-3 small squares
Electrode Limb Lead Placement
White is right
Snow over Grass
Smoke over fire
ECG Determination
Rate
Rhythm (regular/Irregular)
Waves (P-wave before every QRS and QRS after every P)
Intervals (Are they all the same)
Name it (Sinus)
How to determine the rate on a 6s strip
Count the number of QRS Complexes x10
Narrow QRS Complex
Electrical signal made it down super-Highway
Wide QRS Complex
Electrical Signal Stuck at Perkinjie fibers