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agonist
increases the effects of neurotransmitter activity
antagonist
decreases effects of neurotransmitter activity
SSRIs
antidepressants the inhibit the reuptake of serotonin in order to increase serotonin (agonist)
tolerance
repeated exposure causes drug’s effects to lessen, need bigger doses to get the same effect
dependence
craving or need to obtain and use a drug
withdrawal
absence of drug causes physical pain
alcohol use disorder
a problematic pattern of alcohol use leading to significant impairment or distress
alcohol often taken in larger amounts or over a longer period of time than intended
persistent desire or unsuccessful efforts to cut down alcohol use
significant time spent in activities necessary to obtain alcohol, use alcohol, or recover from its effects
recurrent use results in failure to fulfill major role obligations at work, school, or home
recurrent use in situations in which it’s physically hazardous
continued use despite knowing physical or psychological problems are caused or exacerbated by alcohol
reward pathway
VTA → nucleus accumbens → prefrontal cortex
neurotransmitter: dopamine
downregulation
continued drug use reduces number of dopamine receptors in the reward pathway (cause of tolerance)
alcohol
depressant, GABA & glutamate & dopamine agonist
anxiolytics/sedatives & hypnotics
depressant, GABA agonist
opiates/opioids
depressant, endorphin & dopamine agonist
amphetamines/methamphetamines
stimulant, dopamine & norepinephrine agonist
cocaine
stimulant, dopamine & norepinephrine & serotonin agonist
psychedelics/hallucinogens
serotonin agonist
MDMA/ecstasy/molly
part stimulant & psychedelic, dopamine & serotonin agonist
marijuana/cannabis
endocannabinoid agonist
most common drug types in overdoses
opioids & stimulants
sympathetic nervous system
stress, arousal (autonomic, peripheral)
parasympathetic nervous system
rest & digest (autonomic, peripheral)
neural tube
baby nervous system made up of stem cells, eventually forms the brain
synaptogenesis
formation of synapses between neurons
neurogenesis
formation of new neurons in the brain
brain stem
pons, medulla, cerebellum
pons & medulla
essential life functions
cerebellum
coordination, motor activity, muscle memory
limbic system
thalamus, hypothalamus, hippocampus, amygdala, anterior cingulate cortex
thalamus
brain’s central router
hypothalamus
hormones, stress & sleep, pituitary gland
pituitary gland
releases hormones into the bloodstream
hippocampus
long-term memory, distributes memory to store, spatial navigation
amygdala
threat management, emotion & motivation
anterior cingulate cortex
processing emotions & experiences
cerebral cortex
primary and association cortices
primary cortex
sensory and motor info
association cortex
integrate and interpret info for complex thinking
occipital lobe
visual info
temporal lobe
hearing and language comprehension
parietal lobe
sensory, somatosensory cortex
frontal lobe
planning, reasoning, complex thinking, movement, motor cortex
contralateral control
sides of the body are controlled by the opposing brain hemispheres
phantom limb
phantom limb area of the brain still firing when neighboring parts of the brain are active
retina
back of the eye that transforms light waves into action potentials, photoreceptors, bipolar cells, ganglion cells
rods
periphery, dim light
cones
day light, center of retina (fovea), color, visual clarity
optic chiasm
where the two optic nerves cross
feature detectors
neurons in primary visual cortex that fire in response to certain shapes, angles, and movements
dorsal visual stream
occipital → parietal, “where” pathway
ventral visual stream
occipital → temporal, “what” pathway, fusiform gyrus
fusiform gyrus
patch in ventral visual stream that recognizes faces
prosopagnosia
difficulty recognizing faces
top-down processing
perception based on prior experience, knowledge, assumptions, expectations
inattentional blindness
focusing on one thing makes us blind to everything else, thus the brain does not register certain things
cochlea
fluid-filled coil in the inner ear that transforms sound waves into auditory signals
hair cells
cells in cochlea that sense sound waves
taste receptor cells
sensory cells on the taste bud that detect certain tastes and send them to the brain
olfactory receptor cells
sensory cells in the nasal cavity that are activated by odors, message sent to olfactory bulb, then brain
synesthesia
perceptual experience where sensory experience overlaps and associations are made
nociceptors
pain receptors, A-delta fibers and C fibers
a-delta fibers
fast-acting, myelinated, acute pain
c fiber
slow-acting, unmyelinated, dull aching pain
pavlov
classical conditioning, dogs
watson
classical conditioning, little albert
skinner
operant conditioning, skinner’s box
unconditioned stimulus
triggers automatic, natural response
unconditioned response
unlearned, natural response
conditioned stimulus
originally neutral, paired with unconditioned stimulus repeatedly
conditioned response
response to the conditioned stimulus
generalization
after conditioning, tendency to conjure similar responses to similar stimuli
extinction
when the unconditioned stimulus is no longer paired with the conditioned stimulus, and the conditioned response diminishes
systematic desensitization
a form of exposure therapy that exposes the subject to something they are scared of little by little, working to overcome the phobia
positive reinforcement
add a stimulus to get subject to continue a certain behavior (treat, paycheck)
negative reinforcement
take away an aversive stimulus to get subject to continue that behavior (fasten seatbelt to turn off beeping)
fixed-ratio
only reinforcing after a certain # of responses (customer rewards programs)
fixed-interval
only reinforcing after a specified amount of time has elapsed (bi-weekly paycheck)
variable ratio
reinforcing after a random number of responses (gambling)
variable-interval
reinforcing after a random amount of time has elapsed (radio shows)
superstition
forms by falsely linking a behavior to a result (Skinner)
shaping
using operant conditioning & approximations to guide behaviors towards the desired behavior (rodents shaped to locate & signal land mines)
positive punishment
add a stimulus to deter a behavior (spanking)
negative punishment
taking away something to deter a behavior (revoke phone privileges, time-out)
three-stage memory model
sensory, working, long-term
sensory memory
fleeting sensory experience
working memory
actively processed info
long-term
stored info encoded for later
automatic encoding
unconscious encoding (emotional experiences, conditioned learning)
effortful encoding
requires attention & conscious effort (class material)
typical working memory capacity
7 + or - 2
hermann ebbinghaus
studied how to optimize encoding new info
retention curve
as rehearsal time increases, relearning time decreased
serial position effect
tendency to remember the first & last item in a list
spacing effect
increased retention when spacing out practices over time
massed practice
cramming, attempting to encode a lot of info in a short amount of time
daniel tammet
amazing memory and synesthesia, diagnosed with ASD
explicit memory
form of long-term memory that takes effort to retrieve
semantic memory
memory of facts & general knowledge (explicit)
episodic/autobiographical
memory of personally experienced events (explicit)
implicit memory
form of long term memory that don’t take conscious effort to recall
procedural memory
muscle memory, complex motor skills (implicit)
conditioned associations
classical & operant conditioning (implicit)