Regulation of Pyruvate Dehydrogenase Complex
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9 Terms
How does phosphorylation affect E1- pyruvate dehydrogenase
Phosphorylated pyruvate dehydrogenase is inactive
Unphosphorylated pyruvate dehydrogenase is active
What phosphorylates pyruvate dehydrogenase
Pyruvate dehydrogenase kinase
What happens when pyruvate dehydrogenase kinase is stimulates
pyruvate dehydrogenase is phosphorylated and inactive
What stimulates pyruvate dehydrogenase kinase and thus inactivates pyruvate dehydrogenase
High acetyl CoA concentration stimulates
High NADH/NAD+ ratio stimulates
High ATP concentration stimulates
What inhibits pyruvate dehydrogenase kinase and thus allows pyruvate dehydrogenase to be active
High ADP concentration inhibits
High pyruvate concentration inhibits
What dephosphorylates pyruvate dehydrogenase
Pyruvate dehydrogenase phosphatase
What stimulates pyruvate dehydrogenase phosphatase
High Ca2+ concentration stimulates pyruvate dehydrogenase phosphatase
Regulation of E2- dihydrolipoamide acetyltransferase
High acetyl CoA concentration inhibits
High HS-CoA stimulates
Regulation of E3- dihydrolipoamide dehydrogenase
High NADH/NAD+ ratio inhibits
Low NADH/NAD+ ratio stimulates
Note 
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