Blood Bank Media Lab

Anaphylaxis reaction is a…

Associated with transfused patient lacking ___

Severe allergic reaction

IgA

Febrile reaction is a…

Results from recipient ___ cell antibodies causing the release of ___ or donor PLTs release of ___

Fever reaction

white; pyrogens (fever-inducing substance); cytokines

Transfusion-Associated Circulatory Overload (TACO) manifests as ___, occurs when patient’s ___ system cannot handle ___ volume from transfusion.

Congestive heart failure; cardiovascular; additional

Transfusion-Related Acute Lung Injury (TRALI) is caused by ___ antibodies

HLA

Most reliable method for determining the appropriate dosage of Rhogam needed. Why?

Flow Cytometry because it’s an automated quantitative method

Sodium biphosphate is added to stabilize the ___ of the unit during storage

pH

Dextrose is added to help in ___ generation by the ___ pathway

ATP; glycolytic

Adenine is a substrate for ___ synthesis in RBC

ATP

Addition of adenine allows the rbc unit to be stored up to ___ days

35

Citrate Phosphate Dextrose (CPD or CP2D) is stored up to ___ days

21

Irradiated units expire after ___ days from irradiation or on the original expiration date, based on which date occurs first

28

Chronically transfused patients have an increased risk of ___ for developing alloantibodies

>= 30%

Type A

most common in Caucasians

Type B and AB

most common in Asians

Type O

most common in Blacks

Enzyme panels enhance ___ antibodies during antibody identification

Rh

Antibodies that can be destroyed or weakened by enzyme treated panels are

MNS group, Duffy, and Xga

Antibody associated with Mycoplasma pneumoniae infection and cold hemagglutinin disease

Anti-I (“Icy antibody”)

Antibody associated with infectious mononucleosis (Epstein-Barr virus), lymphoproliferative disease, and sometimes with cold hemagglutinin disease

Anti-i (“lil baby i = mono + sleepy lymph nodes)

Antibody associated with paroxysmal cold hemoglobinuria

Anti-P (rbcs lyse at warm temperatures + blood in pee)

Immune hemolytic anemia is confirmed by a positive ___

DAT

Cordocentesis is a procedure used to obtain a fetal blood sample to monitor severity of ___ and can also be used to deliver ___ transfusions.

HDFN; intrauterine

Intrauterine transfusion is performed by accessing the fetal ___ vein (cordocentesis) and injecting donor red blood cells directly into it.

umbilical

Blood group antigen not expressed at all or is weakly expressed on cord blood cells

Le^b

Blood group that usually causes delayed transfusion reactions

Kidd Jka + Jkb (“Little Kidds are always late”)

Washing red cells removes remaining plasma ___ in the unit

proteins

Measles (rubella), mumps, and polio vaccines all have a __ week deferral period following the vaccination.

two

German measles (rubella) vaccine is deferred for ___ weeks following the vaccination.

four

A father carrying the Xga allele will pass it onto only his ___

daughters

ABO antibodies (Anti-A,B), typically from Group O moms, reacting with red cells from Group A or B newborns, can cause symptoms of ___ in pregnancy, usually limited to less severe symptoms than Anti-D induced.

HDFN

Kleihauer-Betke test allows the ___ of fetal and maternal red cells

differentiation

Paroxysmal Cold Hemoglobinuria (PCH) is caused by an ___ antibody; Cold Hemagglutinin Disease (CHD) is usually caused by an ___ antibody

IgG; IgM

Inheritance of both Le and Se genes produce ___ antigen on red blood cells; causing the phenotype ___

Le^b; Le(a-b+)

When determining the immediate outcomes of kidney transplants, ___ compatibility is the most important factor.

ABO

The proper pH for a unit of plts must be > ___

6.2

When calculating RhIG dosage, always add ___ extra does to the calculated dose for an added margin of safety; each dose is effective in treating ___ mL fetal whole blood

one; 30

Are ABO antibodies predominantly IgG or IgM?

IgM

Allergen substances may be drugs or food ___ by the blood donor, potentially causing mild allergic reaction in recipients.

consumed