PREPARATION 7: GLYCERIN SUPPOSITORY

Suppository

This is a dosage form that melts at body temperature

Vaginal suppositories (Pessaries)

Urethral suppositories ( Bougies)

Rectal suppositories

Type of Suppositories

Fatty acid or Oleaginous bases

Water soluble/Miscible bases

Miscellaneous bases

Type of suppository base

Hand rolling 

Fusion 

Compression 

Types of Method of preparation in suppositories (lec based) 

32 mm (1/2 inches)

Size of rectal suppositories

Long, cylindrical, and have one or both ends tapered

Shape of rectal suppositories

Infant: 1 gram

Adult:  2 grams 

Dimenstions of rectal suppositories

Pessaries

Vaginal suppositories other name

Globular, oviform, or conical shaped

Shape of Vaginal suppositories

Abouth 3 to 5 grams

Dimension of vaginal suppository

Bougies

Urethral suppositories other name

Slender, pencil shaped suppositories 

Shape of urethral suppositories 

Males: 4g 100 to 140 mm long 

Females: 2g, 60 to 70 mm long 

Dimension of Urethral suppositories 

Nasal suppositories (Burginarium) 

Aural suppositories ( Ear cones) 

Rare type of suppositories 

Molding from melt/fusion method

Cold compression

Hand molding/rolling/shaping

Compression in a tablet press

Method of preparation (PPT base)

hand molding/rolling/shaping

Oldest method of suppositories

Cocoa butter

Witepsol 

Wecobee 

Types of Fatty or oleaginous base

Theobroma cacao

Scientific name of cocoa butter

Cocoa butter

This is theobroma oil

Natural saturated fatty acid

C12 and C18 

Witepsol contains ______ between _____

Wecobee

This is from the coconut oil

Glycerinated base

Polyethylene glycol base 

Water soluble/miscible base

Jell-O

Glycerinated base contains

Polybase

Polyethylene glycol base contains

Polyoxyl 40 strearate

Miscellaneous base contains

Oleaginous and water soluble bases

Polyoxyl 40 streate is a mixture of?

Suppositoria glycerin

Synoyms of glycerim suppositories

Clear 

Transparent 

Bulleted 

Glycerin suppositories description of final product:

The suppositories is ___ or ___ and it is ___ shaped 

solid dosage form (from other references)

body temperature

Glycerin suppositories description of final product: 

They are ___ and tend to melt at ___

Laxative

Dilation of uterus 

Anti-infective 

erectile dysfunction 

Anti-fungal 

Contraceptives 

Uses of glycerin suppositories

49 or 120 C

Unti what temperature you heat glycerin

Sodium stearate

Solidifying agent of Glycerin suppositories

Water

Vehicle in Glycerin suppositories

Fusion method and molding

The MOP of suppositories

Hygroscopic material

Glycerin is what type of material?

laxative

water

intestine

irritant

mucus

Glycerin contributes to the ____ effect of the suppository by drawing____ from ____ and also its ____ action on ___ lining

Sodium stearate

A soap that is the solidifying agent in teh suppository and may contribute the laxative action