lymphatic and immune systems final

innate immunity (nonspecific)

present at birth, responds to all pathogens the same way

what are the components of innate (nonspecific) immunity

skin, mucous membranes, fever, inflammation, phagocytes (macrophages, neutrophils), natural killer cells

specific immunity (adaptive)

targets specific pathogens, involves memory

what are the components of specific immunity (adaptive)

B cells, T cells, antibodies

anatomy of lymph nodes

• bean shaped, cortex, medulla

• contains lymphatic sinuses that filter lymph

what is the function of lymph nodes

• filter lymph to trap pathogens

• activate immune responses by housing lymphocytes

B cellsl

• produce antibodies to target specific antigens

• responsible for humoral immunity

antibodies

• proteins that bind to specific antigens

• neutralize or mark pathogens for destruction

inflammation

• local response to injury/infection

• redness, swelling, heat, brings immune cells to site

helper T cells

• activate B cells and cytotoxic T cells

• coordinate immune response

cytotoxic T cells

• kill infected or cancerous cells directly

• responsible for cellular immunity

MHC

• proteins that present antigens to T cells

• help immune system distinguish self vs non self

what are locations with large numbers of lymph nodes

neck, armpits, groin, abdominal and thora

diapedesis

movement of WBCs through capillary walls into tissues

autoimmunity

immune system attacks bodys own cells

costimulation

second signal required for full activation of T cells

immunocompetence

ability of immune cells to recognize and respond to antigens