Autoimmune diseases of the endocrine glands

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4 Terms

1
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Why are endocrine glands common targets for autoimmunity?

Because failure of central or peripheral tolerance can lead to immune attacks on them.

2
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What causes loss of central tolerance to endocrine glands?

Tissue-specific proteins may not be displayed to developing lymphocytes.

3
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What happens when tolerance to endocrine proteins is lost?

Autoreactive lymphocytes are produced that can attack endocrine glands.

4
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Which endocrine glands are targeted in organ-specific autoimmune diseases?

The pancreas and thyroid.