M4L1 - Antimicrobials

β-lactams

This is an antibiotic class that inhibits cell wall synthesis

Methicillin

This is a β-lactam antibiotic that is resistant to cleavage from β-lactamase

Aminoglycosides

This is an antibiotic class which binds to the 30S ribosomal subunit to inhibit protein synthesis, includes drugs like genamycin and streptomycin

Tetracyclines

This is an antibiotic class which binds to the 30S ribosomal subunit to inhibit protein synthesis, includes drugs like doxycycline and and minecycline

Macrolides

This is an antibiotic class which binds to the 50S ribosomal subunit to inhibit protein synthesis, includes drugs like erythromycin and azythromycin

Fluoroquinolones

This is an antibiotic class which inhibits DNA synthesis by inhibiting DNA gyrase, includes drugs like ciprofloxacin and moxifloxacin

Isoniazid

This is a cell-wall inhibiting antibiotic which inhibits mycolic acid synthesis, effective in treatment of tuberculosis

Penicillin-binding protein

This is an enzyme that catalyses transpeptidation, targeted by penicillin and derivatives

MRSA

This is a resistant strain of staphylococcus aureus which expresses a cryptic PBP2A not inhibited by methicillin

Transpeptidation

This is the inkage of NAM/NAG-bound peptide chains perpendicular to glycosidic chains in cell wall synthesis

N-acetylglusamine

This is a sugar-derived molecule bound to D-Glu, L-Ala, and D-Ala (NAG)

N-acetylmuramic acid

This is a sugar-derived molecule bound to D-Glu, L-Ala, and D-Ala (NAM)

Diaminopimelic acid

This is a non-amino acid molecule found in the peptide linkages between NAM and NAG