Proton Pump Inhibitors (PPIs)

These flashcards cover key concepts related to Proton Pump Inhibitors (PPIs), their uses, side effects, precautions, and important information for patients.

Proton Pump Inhibitors (PPIs)

Medications that irreversibly block proton pumps to decrease hydrochloric acid production.

Examples of PPIs

Omeprazole (1x a day b4 eating), Pantoprazole, Lansoprazole, Dexlansoprazole, Rabeprazole, Esomeprazole.

Thrombophlebitis

Inflammation of the vein, which can occur at the IV site when administering PPIs.

Upper GI bleeding indication

Notify the provider if there are signs such as coffee-ground emesis.

Short-term treatment duration for ulcers

PPIs should be administered for 4-6 weeks.

Hypomagnesemia

A condition that can arise from long-term PPI use, potentially leading to arrhythmias.

Rebound acid secretion

A phenomenon where, if the drug is abused or used for long periods, more acid is produced after discontinuation.

C. diff

Clostridium difficile, which can be a risk with long-term PPI use.

Interaction with Clopidogrel

PPIs can decrease the effect of Clopidogrel, an antiplatelet medication.

Administration advice for PPIs

Do not crush, chew, or break capsules; do not open capsules and sprinkle on food.