Article 5: adipocyte-derived IL-6 and leptin promote breast cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression

What is the crosstalk between adipocytes and breast cancer cells?

Adipokines from adipocytes activate signaling networks associated with cancer progression, including migration, proliferation, angiogenesis, fibrosis, and apoptosis.

What is the role of lysyl hydroxylase-2 (PLOD2) in breast cancer?

PLOD2 plays a role in the adipocyte-mediated migration of breast cancer cells and is associated with poor prognosis in breast cancer patient

What methods were used in Paper 5 to study PLOD2?

Co-culture systems, qRT-PCR analyses, RNAi knockdown experiments, and mouse models were used to study PLOD2 expression in breast cancer.

What was found about IL-6 and leptin in Paper 5?

IL-6 and leptin increased PLOD2 expression in breast cancer cells, promoting metastasis through the JAK/STAT3 and AKT pathways.

What are the potential clinical implications of PLOD2 in breast cancer?

Inhibition of PLOD2 could suppress breast cancer metastasis to the lungs and liver, providing a potential therapeutic target.