P1 Practice Set for Organic/OrgMedsChemistry/DDD

Proverbs 16:3

cresol

Yellow to brownish-yellow liquid that has a characteristic creosote odor:

cresol

eugenol

resorcinol

hydroquinone

thymol

alopecia

A very common adverse reaction of alkylating agents used in the treatment of cancer:

ataxia

anaphylaxis

alopecia

mydriasis

bulging fontanel

Paul Ehrlich

The scientist who can lay claim to the title of "Father of Chemotherapy":

Paul Ehrlich

Alexander Fleming

August Kekule

Joseph Lister

Friedrich Wohler

1, 2, 3 and 4

Which of the following is/are examples of drugs that are extensively metabolized by first pass effect?

1. Lidocaine

2. Morphine

3. Nitroglycerin

4.Meperidine

1, 2, 3 and 4

1 and 3

2 and 4

2, 3 and 4

1, 2 and 3

sodium dithionite solution

The stain of the urinary analgesic phenazopyridine HCl can be removed using:

bleach

sodium hypochlorite

sodium dithionite solution

oxalic acid

muriatic acid

Selective toxicity

It refers to the property of certain medicinal agent to kill one type of pathogenic microorganisms without harming the host's cell.

Pathogenicity index

Phenol coefficient

Selectively permeability

Selective toxicity

QSARs model

quinine

The following anti-malarials are synthetic drugs, except:

mefloquine

cycloguanil

quinine

chloroquine

primaquine

mebendazole

Inhibition of glucose uptake leading to depleted glycogen storage ==> decrease ATP synthesis

pyrantel pamoate

ivermectin

bithionol

mebendazole

thiabendazole

iodine number

The degree of unsaturation of fats can be determined through:

polarimeter

saponification number

refractive index

iodine number

Fluconazole

Agent of choice for cryptococcal meningitis and DOC for fungal meningitis:

itraconazole

amphotericin B

nystatin

fluconazole

nystatin

Polyene antibiotics for fungi that can act as false membrane component:

fluconazole

nystatin

terbinafine

micafungin

griseofulvin

acyclovir

This drug is used in the treatment of chicken pox:

plecoranil

oseltamivir

acyclovir

fomiversen

zidovudine

Niridazole

All of the following are effective and clinically useful against worm infestation caused by Ascaris lumbricoides, except:

thiabendazole

mebendazole

albendazole

piperazine

niridazole

diuretic

HCTZ is used as:

analgesic

anti-cancer

antibiotics

diuretic

anti-diuretic

3 only

A polyene anti-fungal antibiotic:

1. Griseofulvin

2. Econazole

3. Nystatin

2 only

1, 2 and 3

3 only

2 and 3

1 and 2

2 and 3

An organic compound with a molecular formula of C₄H₈. The compound can be classified as what type of hydrocarbon?

1. Alkane

2. Alkene

3. Cycloalkane

2 and 3

3 only

2 only

1 only

1 and 2

1, 2, 3 and 4

Which among the following is correctly paired:

1. Streptomycin: first anti-TB antibiotic from Strep. griseus

2. Neomycin: from Strep. fradiae (orally active)

3. Paromomycin: Strep. rimosus anti-amebic

4. Kanamycin: Strep. kanamyceticus, tx for bacillary dysentery

ototoxic

mnemonic: amiNOglycoside (N-eurotoxic; O-totoxic)

Streptomycin and other aminoglycoside antibiotics are:

ototoxic

can cause kidney damage

hepatotoxic

can lead to pulmonary fibrosis

carcinogenic

tartaric acid

An acidifying agent employed in effervescent salts and refrigerant drinks:

tartaric acid

citric acid

malic acid

oxalic acid

1, 2 and 3

Sulfanilamide is a generic term that denotes:

1. Aniline-substituted sulfonamides/sulfanilamides

2. Prodrugs that generate active sulfanilamides

3. Non-aniline sulfonamide like mafenide acetate

1 and 3

2 and 3

1, 2 and 3

1 and 2

2 only

adefovir

DOC for chronic form of Hepatitis B:

essentiale forte

adefovir

lamivudine

silymarine

Ampicillin

All of the following antibiotics produce neuromuscular blockade, except:

kanamycin

streptomycin

ampicillin

neomycin

amikacin

clindamycin

The generic name of Dalacin - C which is OFTEN used to treat pimples:

dactinomycin

doxurubicin

clarithromycin

clindamycin

iso-tretinoin

antiretroviral

Group of drugs that can be used for the treatment and management of HIV is called:

immunoglobulins

sulfa drugs

vaccines

antimycobacterial

antiretroviral

8th

The antibacterial activity of alcohol increases with increasing molecular weight until the ___ carbon only.

7th

1st

8th

2nd

10th

Sulfanilamide

The metabolite of the red dye, prontosil, responsible for its antimicrobial property:

sulfapyridine

sulfacetamide

sulfisoxazole

sulfanilamide

inhibitor of reverse transcriptase

Zidovudine is an example of:

Inhibitor of viral DNA Polymerase

Fusion inhibitors

inhibitor of viral RNA polymerase

inhibitor of reverse transcriptase

Etoposide

The anticancer obtained from mayapple or mandrake:

vincristine

topotecan

etoposide

taxol

CH3COOH

Household vinegar is chemically _______

CH3CH2COOH

CH3CH2OH

HCHO

CH3COOH

HCOOH

pseudomonal

Penicillin is the drug of choice for the following anti-infective conditions, except:

pseudomonal

streptococcal

treponema

gonococcal

Penicillin G

Benzyl penicillin is also known as:

p-amino penicillanic acid

Oxacillin

Penicillin G

Penicillin V

3 and 4

Which among the following is correct about aminoglycosides?

1. Contains beta-lactam dihydrothiazine ring

2. Derivative of 7-aminocephalosporanic acid

3. Contain a highly substituted 1,3-diaminocyclohexane central ring

4. Strongly basic antibiotics

acyclovir

Which among the following drug is considered as the drug of choice for chicken pox?

vancomycin

co-trimoxazole

adefovir

chloramphenicol

acyclovir

ACE inhibitor

Captopril is an example of:

HMG CoA inhibitor

MAO inhibitor

COX inhibitor

ACE inhibitor

myelosuppression

A very common adverse reaction of alkylating agents used in the treatment of cancer:

ataxia

alopecia

mydriasis

pulmonary fibrosis

myelosuppression

macrolides like erythromycin

For patients allergic to penicillin, this drug is used as alternative:

co-amoxiclav

macrolides like erythromycin

ampicillin

amoxicillin

depot penicillin

ketoconazole

First orally active broad spectrum imidazole antifungal:

clotrimazole

miconazole

ketoconazole

itraconazole

fluconazole

bicalutamide

An androgen receptor antagonist:

depo-provera

megestrol acetate

bicalutamide

tamoxifen

lamivudine

Nucleoside analogue similar to ddC:

azidothymidine

stavudine

zalcitabine

lamivudine

oil of wintergreen

Methylsalicylate is also known as:

juniper oil

oil of wintergreen

toothache drops

otto of rose

jasmine oil

chloramphenicol

Gray-baby syndrome is usually associated in which among the following antibiotics?

chloramphenicol

vancomycin

piperacillin

sulfonamide

tobramycin

streptozotocin

Which among the following alkylating agents can induce hyperglycemia on animal models?

streptomycin

streptozotocin

alloxan

altrenamine

dactinomycin

The first antibiotic with anti-malignant property that binds non-covalently to double-stranded DNA by partial intercalation between the adjacent G-C bases resulting in inhibition of DNA function:

bleomycin

doxorubicin

dactinomycin

daunorubicin

amantadine

Antiviral that has effect as anti-Parkinsonian agent:

amantadine

remdesivir

tocilizumab

lamivudine

anti-diarrheal

Loperamide is commonly used for/as:

cathartic

anti-diarrheal

anthelmintics

antacid

stimulant laxative

co-trimoxazole

The combination of trimethoprim and sulfamethoxazole is also known as:

sultamicillin

co-amoxiclav

co-trimoxazole

urobitioc

azo-gantrisin

Citric acid

A hydroxy tribasic acid occurring in sour fruits like oranges, calamansi and lemon, extensively used in the softdrinks industry.

oxalic acid

malic acid

tartaric acid

lactic acid

citric acid

streptomycin

The following antibiotic possess clinically useful anti-malignant property, except:

streptomycin

bleomycin

daunorubicin

plicamycin

mitomycin

sulfasalazine

Prodrug (m-aminosalicylic acid and sulfapyridine; effective in treating ulcerative colitis):

sulfixosazole

mafenide acetate

silver sulfadiazine

sulfasalazine

trimethoprim

capecitabine

Which among the following is not an example of purine analog?

capecitabine

cladribine

fludarabine

6-mercaptopurine

valacyclovir

Prodrug of Acyclovir with better bioavailability:

ganciclovir

penciclovir

valacyclovir

famciclovir

Melarsoprol

DOC for later stages of African trypanosomiasis:

melarsoprol

nifurtimox

metronidazole

eflornithine

suramin sodium

1 and 3

The alkaloid from Ipecac is commonly employed as:

1. Emetic

2. Analgesic

3. Anti-protozoal

chloroacetaldehyde

The primary metabolic product of cyclophosphamide:

Chlorambucil

Chloroacetaldehyde

Melphalan

Sulfur stripping

Mesna

Cloxacillin

Which of the following penicillin is resistant to penicillinase?

Thienamycin

Carbenicillin

Flucloxacillin

Cloxacillin

Polymyxin B

Oxalic acid

A dicarboxylic acid used as rust and stain remover:

Citric acid

Acetic acid

Tartaric acid

Formic acid

Oxalic acid

Urinary analgesic

Indication of phenazopyridine HCl?

Urinary analgesic

Urinary antiseptic

Antibacterial dye

Anti SARS-COV2

Anti-protozoal

Phenol

A general protoplasmic poison:

Ethylene oxide

Salvarsan

Isopropyl alcohol

Dimercaprol

Phenol

Pentafuside

Inhibits formation of the fusion component conformation of gp41:

Delavirdine

Pentafuside

Indinavir

Efavirenz

formaldehyde

Methenamine is decomposed into __ at a urine pH of 5.5. This is responsible for methenamine's urinary tract antiseptic property.

Acetone (as ketone body)

Ethyl alcohol

Formaldehyde

Ethylene glycol

Acetic acid

Oseltamivir

Which among the following drug can be used for viral influenza:

Amoxicillin

Acyclovir

Oseltamivir

Metronidazole

Vidarabine

Imipenem

Which among the following is/are example of beta-lactamase inhibitor, except:

1. Thienamycin

2. Imipenem

3. Tazobactam

Peptide bond

Amides are found in what type of bond?

Peptide bond

Alcohol

Amino acids

Ester

Amine

Amphotericin B

For the treatment of systemic mycosis, which of the following antifungal agents can be administered by intravenous route?

Clotrimazole

Nystatin

Ketoconazole

Miconazole

Amphotericin B

Salicylic acid

Orthohydroxybenzoic acid is:

Citric acid

Salicylic acid

Salicylaldehyde

Oxalic acid

Acetic acid

Ganciclovir

Analogue of acyclovir with an additional hydroxymethyl group on the acyl side chain:

Famciclovir

Ganciclovir

Acyclovir

Valacyclovir

Topoisomerase II

Doxorubicin inhibits:

Topoisomerase I

Tubulin synthesis

Topoisomerase II

DNA polymerase

Protein kinases

Inhibitor of viral DNA Polymerase.

Mechanism of action of Idoxuridine:

Inhibitor of viral DNA Polymerase

Fusion inhibitor

Inhibitor of viral RNA polymerase

Inhibitor of reverse transcriptase

Dyslipidemia

Common adverse reaction of HIV Protease inhibitors:

Rapid release of histamine (redness)

Rashes

Dyslipidemia

Atherosclerosis

Mefloquine

Newest and most potent quinoline derivative for malaria:

Chloroquine

Quinine

Mefloquine

Atabrine

Amodiaquine

Penicillin G

Acid resistant, except:

Penicillin G

Penicillin V

Ampicillin

Amoxicillin

sulfa drugs

The collective term given to aniline-substituted sulfonamides/sulfanilamides:

HAART

silver sulfadiazine

prodrug

TB-DOTS

sulfa drugs

4th generation has higher gram - activity as compared with 1st generation

Which among the following statement is correct about cephalosporins?

-3rd generation has the highest gram - activity as compared with the 1st generation

-1st generation has higher gram - activity as compared with 3rd generation

-2nd generation has the highest gram - activity as compared with the 1st generation

-4th generation has higher gram - activity as compared with 1st generation

Conjugation reaction & Phase II Metabolism

The main goal of this metabolic reaction is to attach small, polar, ionizable endogenous substrates:

Conjugation reaction

Phase II Metabolism

Functionalization reaction

Phase I Metabolism

vidarabine

Which among the following is an example of a pyrimidine analog, except:

vidarabine

tegafur

cytarabine

decitabine

5-fluorouracil

All of the above

Which of the following is/are true regarding phase II drug metabolism?

-allows attachment of small, polar, and ionizable endogenous compounds

-allows termination or attenuation of a biological activity

-serves to protect the body against chemically reactive compounds or metabolites

ROR

What is the type of the chemical Methoxyethane?

RCHO

RCOOR

ROR

RCOR

RCOOH

HAART

Lamivudine, Tenofovir, Efavirenz are a combination of anti-HIV drugs that is commonly called as:

TMP-SMX

CMC

HAART

MDMA

MTX

kidneys

Major organ for excretion:

skin

liver

lungs

kidneys

periwinkle

The plant containing the anti-cancer drug, vincristine and vinblastine:

mandrake

taxol

campthoteca

periwinkle

mayapple

benzoyl peroxide

This agent can induce proliferation of epithelial cells leading to sloughing and repair:

carbamide peroxide

salicylic acid

benzoyl peroxide

benzyl benzoate

hydrogen peroxide

streptomycin

The most active aminoglycoside against Mycobacterium tuberculosis is:

neomycin

ethionamide

levofloxacin

streptomycin

isoniazid

antiseptics

Compounds that kill or prevent the growth of microorganisms when applied to living tissues:

astringents

antiseptics

protoplasmic poison

antimicrobials

disinfectants

benzalkonium chloride

The present day "gamot na pula" contains:

cetylpyridinium chloride

benzalkonium chloride

benzoyl peroxide

thimerosal

nitromersol

Tazobactam

A beta-lactamase inhibitor with penicillanic acid sulfone:

piperacillin

tazobactam

clavulanic acid

sulbactam

they are obtained from the genus Streptomyces

Correct: Penicillium genus (specifically Penicillium chrysogenum)

All of the following statements are true concerning penicillins, except:

-this class of anti-bacterials act by damaging the cell walls of bacteria

-they are obtained from the genus Streptomyces

-piperacillin and ticarcillin have activity against Pseudomonas species

-use of any penicillin is contraindicated in a patient who has had an allergic reaction to any one penicillin

-the addition of clavulanic acid to amoxicillin preparations protects the drug from penicillinase

anti-pyretic

Paracetamol is commonly used as:

anti-cholinergic

an example of neurotransmitter

an example of MAOIs

anti-pyretic

opioid analgesic

Isoniazid

Which among the following combinations used for TB can commonly cause peripheral neuropathy?

pyrazinamide

Isoniazid

rifampicin

ethambutol

Vitamin B6

Hepatotoxicity

Common side effects of Aminoglycoside antibiotics, except:

Hepatotoxicity

Nephrotoxicity

Ototoxicity

chloramphenicol

The drug of choice for typhoid fever:

blood dyscrasias

chloramphenicol

artemisinin

quinine

paracetamol

1 and 2

Correct about carbol-fuschin:

1. Component of Castellani's paint

2. Treatment of fungal infections

3. Mixture of chloride of rosaniline and p-rosaniline chloride

urothropin

Methenamine is also called:

uric acid

urophthropin

azo-gantrisin

pyrazinoic acid

uridine

penicillamine

This is an effective antidote for the treatment of copper poisoning:

penicillamine

deferoxamine mesylate

dimercaprol

BAL

lomefloxacin

The most phototoxic quinolone:

moxifloxacin

levofloxacin

lomefloxacin

ciprofloxacin

sparfloxacin

they can cause yellow atrophy of the liver in the mother

Long-term use of tetracyclines in pregnant women should be avoided due to several reasons. Which of these is not true?

-they get deposited in growing bones

-they predispose to discoloration of deciduous teeth in infant

-they can cause yellow atrophy of the liver in the mother

-they are toxic to the fetus and may cause abortion

-they chelate calcium ions

methylene blue

Which among the following is an example of a thiazine dye?

methylene blue

crystal violet

gentian violet

basic-fuchsin

pyridoxine

Neurotoxicity caused by isoniazid can be treated with:

thiamine

cyanocobalamine

pantothenic acid

tocopherol

pyridoxine

soaps

Benzalkonium chloride is a germicidal surfactant which is rendered inactive in the presence of:

soaps

organic acids

GPB

cationic surfactants

GNB

raltegravir

An example of an integrase inhibitor:

ritonavir

raltegravir

indinavir

remdesivir

pentafuside

tobramycin

Most active nebramycins, effective against conjunctivitis:

amikacin

tobramycin

streptomycin

gentamicin