Untitled Flashcards Set

IBUPROFEN NSAID Propionic acid derivatives Route of Administration : ORAL, IV DICLOFENAC NSAID Aryl acetic acid derivative Route of Administration : ORAL KETOROLAC NSAID Pyrolo pyrole derivative Route of Administration : ORAL, IM MECHANISM OF ACTION : INHIBITS THE SYNTHESIS OF PROSTAGLANDIN BY INHIBITING COX1 & COX 2 ENZYMES THERAPEUTIC USES : ANALGESIC HEADACHE, OROFACIAL PAIN ANTIPYRETIC FEVER ANTI-INFLAMATORY RHEUMATOID ARTHRITIS, OSTEOARTHRITIS DYSMENORRHEA MEDICAL CLOSURE OF PATENT DUCTUS ARTERIOSUS ADVERSE DRUG REACTIONS : HYPERSENSITIVITY PEPTIC ULCER POST OPERATIVE PAIN NA AND WATER RETENTION - EDEMA PREMATURE CLOSURE OF DUCTUS ARTERIOSUS POST OPERATIVE PAIN

Ibuprofen

A nonsteroidal anti-inflammatory drug (NSAID) and propionic acid derivative, administered orally or intravenously, used as an analgesic, antipyretic, and anti-inflammatory.

Diclofenac

An NSAID that is an aryl acetic acid derivative, administered orally, used for analgesic and anti-inflammatory effects.

Ketorolac

An NSAID that is a pyrolo pyrole derivative, administered orally or intramuscularly, used as a strong analgesic.

Mechanism of Action of NSAIDs

Inhibit the synthesis of prostaglandins by inhibiting COX-1 and COX-2 enzymes.

Therapeutic Uses of NSAIDs

Used for analgesia (e.g., headache, orofacial pain), antipyresis (fever), and anti-inflammation (e.g., rheumatoid arthritis, osteoarthritis, dysmenorrhea, and medical closure of patent ductus arteriosus).

Adverse Drug Reactions of NSAIDs

Includes hypersensitivity, peptic ulcer, postoperative pain, sodium and water retention (edema), premature closure of ductus arteriosus.