Metronidazole (DNA synthesis inhibitors

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Last updated 3:51 PM on 9/8/26
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6 Terms

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Metronidazole

  • inhibit synthesis of DNA in bacteria and other organism

  • Bactericidal

  • Effective agaisnt anaerobic bacteria or protozoans

  • Narrow spectrum


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How to take metronidazole

  • IV per orally or topical cream

  • Penetrates well intro body tissues and fluids

  • Does not cross over the placenta


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Metronidazole effective against

  • Anaerobic bacterial infections- clostridium difficile, H. Pylori, Lactobacillus species

  • Protozoan infections- amoebiasis, trichomonads vaginalis, giardiasis


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Where is metronidazole metabolized

  • in the liver

  • Inhibitor of CYP450 enzyme → slow down metabolism of other medicines


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Side effects of metronidazole

  • decreased appetite, nausea, metallic taste in the mouth, headaches, stomach cramps, neurological effects (seizures, confusion, peripheral neuropathy)


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Contradictions of metronidazole

  • first trimester of pregnancy

  • Alcohol