Drug Quiz #1 (2026-2027) - Beta Blockers

Propranolol (Brand Name)

Inderal (LA), Innopran XL

Propranolol (MOA)

Competitively blocks beta-1 and beta-2 receptors

Propranolol (FDA Indication; Off Label Use)

Angina, Cardiac dysrhythmias, Hypertension, Migraines; Anxiety

Propranolol (Dosage Form; Dosage; Hepatic/Renal Dosage)

Oral, IV; HTN: 40 mg BID, may titrate to 240 mg QD in 2-3 doses, Migraines: 40-80 mg QD in divided doses, may titrate to 240 mg QD; Hepatic: N/A, Renal: N/A

Propranolol (Drug Interaction)

CYP1A2 inducers, 2D6 inhibitors, NSAIDs, antidiabetic drugs, calcium channel blockers, alpha-blockers, digoxin

Labetalol (Brand Name)

Normodyne, Trandate

Labetalol (MOA)

Selective α1- and nonselective β-adrenergic receptor blocker

Labetalol (FDA Indication; Off Label Use)

Hypertension; N/A

Labetalol (Dosage Form; Dosage; Hepatic/Renal Dosage)

Oral, IV; 100 mg BID; may titrate in 100 mg increments BID every 2-3 days to maintenance dose of 200-400 mg BID, max dose 2400 mg QD; Hepatic: N/A, Renal: N/A

Labetalol (Drug Interaction)

CYP1A2 inducers, 2D6 inhibitors, NSAIDs, antidiabetic drugs, calcium channel blockers, alpha-blockers, digoxin

Carvedilol (Brand Name)

Coreg

Carvedilol (MOA)

Selective α1- and nonselective β-adrenergic receptor blocker

Carvedilol (FDA Indication; Off Label Use)

Hypertension, Heart Failure; Angina, atrial fibrilation, myocardial infarction, nonsustained ventricular tachycardia or ventricular premature beats, variceal hemorrhage

Carvedilol (Dosage Form; Dosage; Hepatic/Renal Dosage)

Oral; HTN: 6.25 mg BID; Hepatic: Avoid use in patients with hepatic impairment; contraindicated in severe liver dysfunction, Renal: N/A

Carvedilol (Drug Interaction)

CYP1A2 inducers, 2D6 inhibitors, NSAIDs, antidiabetic drugs, calcium channel blockers, alpha-blockers, digoxin

Atenolol (Brand Name)

Tenormin

Atenolol (MOA)

Competitively inhibits beta-1 adrenergic receptors

Atenolol (FDA Indication; Off Label Use)

Hypertension, Angina; Cardiac dysrhythmia, Migraine prophylaxis, Marfan syndrome with aortic aneurysm, Thyrotoxicosis

Atenolol (Dosage Form; Dosage; Hepatic/Renal Dosage)

Oral, IV; HTN: 25 mg QD, titrate to 100 mg QD; Hepatic: N/A, Renal: CrCl 10-30 mL/min - max dose 50 mg QD; CrCl <10 mL/min - max dose 25 mg QD

Atenolol (Drug Interaction)

CYP1A2 inducers, 2D6 inhibitors, NSAIDs, antidiabetic drugs, calcium channel blockers, alpha-blockers, digoxin

Bisoprolol (Brand Name)

Zebeta

Bisoprolol (MOA)

Competitively inhibits beta-1 adrenergic receptors

Bisoprolol (FDA Indication; Off Label Use)

Hypertension; Angina, atrial fibrillation, heart failure, ventricular arrhythmias

Bisoprolol (Dosage Form; Dosage; Hepatic/Renal Dosage)

Oral; 2.5-5 mg QD, may titrate to max of 20 mg QD; Hepatic: Initiate with 2.5 mg QD, may titrate to max of 10 mg QD (hepatitis or cirrhosis), Renal: Initiate with 1.25-2.5 mg QD, may titrate to max of 10 mg QD (CrCl <20 mL/min)

Bisoprolol (Drug Interaction)

CYP1A2 inducers, 2D6 inhibitors, NSAIDs, antidiabetic drugs, calcium channel blockers, alpha-blockers, digoxin

Metoprolol succinate (Brand Name)

Toprol-XL

Metoprolol succinate (MOA)

Competitively inhibits beta-1 adrenergic receptors

Metoprolol succinate (FDA Indication; Off Label Use)

Angina, Heart Failure, Hypertension, Acute Myocardial Infarction; Atrial Fibrillation, ventricular rate control, Cardiac Dysrhythmia

Metoprolol succinate (Dosage Form; Dosage; Hepatic/Renal Dosage)

Oral; HTN: 25-100 mg QD; Hepatic: Liver disease - titrate slowly, Renal: N/A

Metoprolol succinate (Drug Interaction)

CYP1A2 inducers, 2D6 inhibitors, NSAIDs, antidiabetic drugs, calcium channel blockers, alpha-blockers, digoxin

Metoprolol tartrate (Brand Name)

Lopressor

Metoprolol tartrate (MOA)

Competitively inhibits beta-1 adrenergic receptors

Metoprolol tartrate (FDA Indication; Off Label Use)

Angina, Hypertension, Acute Myocardial Infarction; Atrial Fibrillation, ventricular rate control, Cardiac Dysrhythmia

Metoprolol tartrate (Dosage Form; Dosage; Hepatic/Renal Dosage)

Oral, IV; HTN: 50 mg BID; Hepatic: Liver disease - titrate slowly, Renal: N/A

Metoprolol tartrate (Drug Interaction)

CYP1A2 inducers, 2D6 inhibitors, NSAIDs, antidiabetic drugs, calcium channel blockers, alpha-blockers, digoxin

Nebivolol (Brand Name)

Bystolic

Nebivolol (MOA)

Competitively inhibits beta-1 adrenergic receptors

Nebivolol (FDA Indication; Off Label Use)

Hypertension; N/A

Nebivolol (Dosage Form; Dosage; Hepatic/Renal Dosage)

Oral; 5 mg QD; may titrate Q2W to max 40 mg/d; Hepatic: Moderate hepatic dysfunction - initial dose 2.5 mg po daily, titrate carefully - Severe impairment - avoid, Renal: CrCl <30 mL/min - initial dose 2.5 mg po daily, titrate carefully

Nebivolol (Drug Interaction)

CYP1A2 inducers, 2D6 inhibitors, NSAIDs, antidiabetic drugs, calcium channel blockers, alpha-blockers, digoxin