part 1: INTRODUCTION

Drug

Agent intended for use in the mitigation, cure, treatment, prevention, or diagnosis of disease in humans or in other animals

Edrophonium

Drug used in diagnosing Myasthenia Gravis

Tensilon Test

Test in diagnosing Myasthenia Gravis

Dipyridamole

Drug used for Pharmacologic Stress Test

Excipients

Any component, other than the active substance(s), present in a medicinal product or used in the manufacture of the product

Necessities or Pharmaceutical Adjuncts

Excipients are also known as?

1. Cost

2. Compatibility

3. Effect on Efficacy

Considerations in choosing Drug Excipients

Lead Compound

Prototype chemical compound that has a fundamental desired biologic or pharmacologic activity

Cimetidine

Lead compound of H2 Antagonist

Chlordiazepoxide

Lead compound of Benzodiazepines

Cephalosporin C

Lead compound of Cephalosporins

Nalidixic acid

Lead compound of Quinolones

Prodrug

A compound that requires metabolic biotransformation after administration to produce the desired pharmacologically active compound

Prodrug

May be designed preferentially for solubility, absorption, biostability, and prolonged release

Enalaprilat

Active metabolite of Enalapril maleate

Oxophenarsine

Active metabolite of Arsphenamine

Compound 606 or Salvarsan

Arsphenamine is also known as?

Orphan Drug

A drug or biologic product for the diagnosis, treatment, or prevention of a rare disease or condition

Acromegaly

Disease due to overproduction of growth hormone

Octreotide

Drug used for Acromegaly

API or Active Ingredient

Any component that is intended to furnish pharmacologic activity or to affect the structure or function of the body of man or other animals