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Ingestion
The intake of food into the digestive system.
Propulsion
The movement of food through the digestive tract, including peristalsis and segmentation.
Peristalsis
Wavelike muscular contractions to move food along the digestive tract.
Segmentation
Rhythmic contractions mixing food with digestive juices.
Oral cavity
The area where ingestion, mechanical digestion (mastication), mixing food with saliva, taste, and limited chemical digestion occur.
Saliva
A fluid that lubricates food, begins starch/lipid digestion, cleans the mouth, and dissolves chemicals for taste.
Tooth parts
Includes enamel (hard protective coating), dentin (support and shock absorption), pulp cavity (contains nerves and blood vessels), and cementum (anchors tooth via periodontal ligament).
Dental succession
The replacement of 20 deciduous teeth with 32 permanent teeth.
Tooth decay
Bacterial acids erode enamel and dentin.
Esophagus histology
Stratified squamous epithelium resists abrasion; muscularis enables peristalsis.
Deglutition
The process of swallowing, which includes voluntary oral phase, involuntary pharyngeal phase, and involuntary esophageal phase.
Stomach anatomy
Muscular layers churn food; gastric glands secrete enzymes, HCl, and mucus.
Gastric secretory cells
Include parietal cells (HCl, intrinsic factor), chief cells (pepsinogen, gastric lipase), mucous cells (mucus), and G cells (gastrin).
HCl formation
Parietal cells pump H+ from carbonic acid breakdown; Cl- follows into lumen.
HCl functions
Kills microbes, denatures proteins, and activates pepsinogen.
Stomach protection
Provided by thick alkaline mucus and rapid epithelial turnover.
Gastric secretion regulation
Includes cephalic (CNS stimulates gastric juice before food arrives), gastric (stretch/chemoreceptors → gastrin release → increased secretion/motility), and intestinal (chyme in duodenum slows gastric activity via inhibitory hormones).
Gastroenteric reflex
Stimulates motility and secretion along the small intestine.
Gastroileal reflex
Opens the ileocecal valve.
Small intestine
The primary site for nutrient absorption, with the jejunum being the most absorptive, duodenum secreting most digestive enzymes/bicarbonate/mucus, and ileum absorbing vitamin B12 with intrinsic factor.
Pancreas exocrine secretions
Digestive enzymes (amylase, lipase, proteases) and bicarbonate.
Liver microanatomy
Includes portal triads that deliver blood, sinusoids that filter, Kupffer cells that remove debris, hepatocytes that process nutrients, and a central vein that drains.
Bile
Produced by hepatocytes, stored in the gallbladder, emulsifies fats, and is reabsorbed in the ileum and returned via enterohepatic circulation.
Duodenal hormone effects
Includes gastrin (↑ gastric acid/motility), secretin (↑ bicarbonate, ↓ gastric activity), GIP (↓ gastric activity, ↑ insulin release), CCK (↑ pancreatic enzymes, gallbladder contraction), and VIP (dilates capillaries, ↑ secretion, ↓ acid).
Large intestine
Responsible for water/electrolyte absorption, vitamin production, and feces formation.
Mass movements
Strong peristalsis that moves feces to the rectum.
Defecation reflex
Stretch → parasympathetic stimulation → internal sphincter relaxes → voluntary external sphincter control.
Microbiota
Mostly found in the large intestine; aids digestion, vitamin synthesis, and immune modulation.
Carbohydrate digestion
Involves amylase breaking down carbohydrates into disaccharidases and then monosaccharides absorbed via cotransport.
Lipid digestion
Bile emulsifies fats, lipase breaks them down into micelles, which are absorbed into lacteals.
Protein digestion
Proteases break down proteins into amino acids via active transport.
Ion absorption
Occurs through diffusion, active transport, and cotransport; major ions include Na+, K+, Ca2+, Mg2+, Cl-, phosphate, bicarbonate.
Vitamin definition
An organic compound needed in small amounts for metabolism.
Fat-soluble vitamins
Includes vitamins A, D, E, K, which are absorbed with fats.
Water-soluble vitamins
Includes vitamins B and C, which are absorbed via diffusion or active transport.
Age-related changes
Includes reduced motility, enzyme/acid secretion, taste/smell; increased constipation and malnutrition risk.