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What is epigenetics?
is the study of heritable traits, or a stable change of cell function, that happen without changes to the DNA sequence.
What did the Minnesota Twin Experiment show?
35 years of research
Discovered twins reared apart have many similarities.
What does dizyogtic mean? (hint twins)
Two eggs
What does monozygotic mean? (hint twins)
One egg
Who were the Jim Twins
The Jim Twins of Ohio were reunited at age 39, after being separated at birth. When they got to talking, they found that they had lived identical lives!
their adoptive parents coincidentally named them both James
Both had beloved childhood dogs named Toy, and as schoolchildren, both had a proclivity for math and woodworking but were no great shakes at spelling. If their childhoods were uncannily similar, though, then their early adulthoods were truly remarkable.
Both Jims had married twice. The first time, they married women named Linda. When this didn’t work out and they divorced, they met (and went on to marry) women named Betty. Both Jim Lewis and Jim Springer had a son, and –I’m sure you saw this coming—both gave their boy the same name, James Alan (or James Allan in Springer’s case).
Both Jims were heavy smokers, drove the same car (a Chevrolet) and had similar jobs in security (Jim Lewis was a security guard, while Jim Springer had been a deputy sheriff). They even took vacations at the same Florida beach. N
What is the peripheral nervous system?
It is the nerves. It carries information too and away from the nervous system. It’s also divided into two parts, called the somatic and the autonomic.
What does the somatic nervous system do?
Communicates sensory information via sensory neurons to Central NS
Motor neurons take info about what to move and how to move from CNS to muscles
What does the autonomic nervous system do and what categories is it categorized into?
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What does the sympathetic nervous system do?
Fight or flight response
Increases: heart rate, blood pressure, respi
ration, stress hormones
Dilates pupils
Decreases: digestion and saliva production
What does the parasympathetic system do?
Rest and digest – calms body after fight or flight response
Does opposite of what sympathetic does
What does the central nervous system consist of?
It consists of the brain and spinal cord
What are glial cells and what do they do?
help support, connect, and protect the neurons of the central and peripheral nervous systems. They come in many shapes, sizes, and types, each performing specialized functions. In the CNS, glial cells regulate neurotransmission and help form the blood-brain barrier. They can’t communicate with electricity
What do sensory or afferent nuerons do?
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What do motor or efferent nuerons do?
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What does a typical nueron have?
A dendrite, soma (body), axons, nucleus, some have myelin sheaths, axon terminals, and terminal buttons
How do synapses help?
Has a synaptic gap between neurons and the neurotransmitters cross and lock into the dendrite to fire it
What acronym can help students remember the anatomy of a nueron?
D(endrite)S(oma)A(xon)T(erminal)s(ynapse)
What is action potential?
a rapid sequence of changes in the voltage across a membrane.occurs when a neuron sends information down an axon, away from the cell body.
What are the steps of action potential?
Resting Potential
-70 millivolts → Polarized (Positive Outside)
Firing Threshold
All or none
The neuron will fire with the SAME intensity every time
Action Potential
The electrical impulse that goes down the axon
Electricity creates a positive electrical charge
Depolarization
Refractory Period
Neurons can’t fire for a brief period
Reuptake
Sending neurons to recollect neurotransmitters
What does the neurotransmitter gluatmate do and is it inhibitory or excitory?
Most abundant excitatory neurotransmitter~Enhances learning and memory by strengthening synaptic connections
What does the nuerotransmitter GABA (gamma-animutyric acid)
Most abundant inhibitory neurotransmitter. Associated with various anxiety-related disorders
Where is acetylcoline found and what does it do?
Found in both central and peripheral
All movement involves ACh
Involved in learning and memory
Alzheimer’s is associated with diminished ACh functions
What does dopamine do?
Linked to the anticipation of pleasurable or rewarding activities
Also involved in movement, attention, and learning
Lack of dopamine is associated with Parkinson’s
Exces dopamine is associated with schizophrenia
What do endorphins do?
Body’s natural painkiller
Stimulated by intense/prolonged exercise creating euphoria
Excitatory
What does enipherene (adrenaline) do?
Primary fight or flight response
Exitatory
Both a neurotransmitter and hormone that boosts energy
What does Norepinephrine (Noradrenaline) do?
Arousal, alertness, vigilance
Heavily involved in the sleep cycle
Low levels are associated with depression
What does serotonin do?
Plays a role in mood, appetite, sleep, and dreaming
Low levels are associated with depression
What do agonists do?
enhances actions of neurotransmitter
What are some examples of indirect agonists?
Reuptake inhibitors
A blockade that blocks the reuptake channel
Prozac
Inhibits reuptake of serotonin
Cocaine
Inhibits reuptake of dopamine
What are some examples of direct agonists?
Heroin, Nicotine, Black widow toxin
What do antagonists do?
Block neurotransmitter from being released to the receptor site
What are some examples of antagonists?
Botox
Antagonist for ACh and blocks it from reaching receptors
Thorazine
Drugs for Schizophrenia and block dopamine receptors
What is the blood-brain barrier?
The semi-permeable membrane that allows some chemicals from the blood into the brain
What do depressents do?
Slow or inhibit the central nervous system
Create drowsiness, sedation/sleep and can relieve anxiety or lower inhibition
THESE CAN BE DEADLY IF COMBINED
What do opiods/opidates do?
Agonist for endorphins
Heroin, Oxycodone, Fentanyl
Incredibly addictive
What do stimulants do?
Activate the sympathetic nervous system
Increase brain activity, arouse behavior, and increase mental alertness
What are some examples of common stimulants?
Caffeine
The most widely used drug in the world
Promotes wakefulness by stimulating the release of dopamine
Antagonist for adenosine
Cocaine
Dopamine agonist
Crash after high dissipates
What do hallucinogens (psychedelics) do?
Create sensory and perceptual distortions, alter mood, and affect thinking
THC
Mild hallucinogen
In “Hippy grass” and produces a sense of well-being, euphoria, and state of relaxation.
What does the medulla obloganda do?
basic autonomic functions
Heart rate
Breathing
BP
What is a reflex and what are some common examples of a reflex?
A reflex is a response to stimuli that the brain is not directly involved in. Examples include moving your hand after you touched something hot.
What does the pons do?
Connects brainstem and cerebellum
Coordinate and integrate movements on each side of the body
Role in sleep and dreaming
What does the Reticular Activating System or Reticular Formation do?
Network involved in attention, arousal, and alertness
What does the cerebellum do?
Balance and equilibrium
Coordinated sequences of movement
Implicit memory
What does the midbrain do?
Nerve system connecting higher and lower portions
Relays info between the brain, ears, and eyes
What parts to the limbic system consist of?
Thalamus, hypothalamus, amygdala, and hippocampus
What does the thalamus do?
Sensory switchboard
Receives and sorts sensory information and sends it to where it goes.
EXCEPT SMELL
What does the hypothalamus do?
Fight or flight
Feeding
Fornication
What does the amygdala do?
Anger
Aggression
Afraid (fear response)
Plays a role in emotional memories
What does the hippocampus do?
Converts short-term memory into long-term memory
Involved in processing and retrieving declarative memory
Spatial relationship memories
Dysfunction: Alzhemier’s and anterograde amnesia
What does the limbic system do?
The limbic system is involved in emotions, memory, integration of sensory info, and motivation.
How many lobes does the cortex have?
4
How many hemispheres does the cortex have?
2
What does the prefrontal cortex/most of the frontal lobe do?
Thinking, planning, decision-making, impulse control
What does the motor cortex do?
Initiating voluntary movement
Contralateral (left controls right)
Body areas that make diverse and precise movements get more tissue
What does the parietal lobe do?
Somatosensory
A strip of tissue represents a sense of touch
Contralateral
Parts of the body more sensitive has more tissue devoted to this strip
What does the occiputal lobe do?
Primary Visual cortex
What does the temporal lobe do?
Primary auditory cortex
Auditory Association cortex
What does the cerebral cortex do?
Primary auditory cortex
Auditory Association cortex
What does the collosum do?
Bundle of nerves connecting two hemispheres
Allows constant communication between right and left hemisphere
What is split brain research and what is its benefit?
It can help relive epilepsy
What is brain lateralization and an example of this?
Somethings tend to be lateralized to left or right
Language is left hemisphere
Broca’s area
What is the left hemisphere?
Language (expression, comprehension, reading)
Interpreter
what is the right hemisphere?
Spatial abilities Facial recognition Stronger at controlling and recognizing emotional expression More active creating/appreciating art/music |
What is nueroplasticity?
Throughout life, the brain can grow new connections and new neurons
Ability to change is a result of experience or injury
Examples
Neurogenesis
Long-term potentiation
What is neurogenesis and what can influence it?
Creation of new cells
Exercise increases it and social isolation decreases it
What is structural plasticity?
long term potentiation
When a network of neurons fires together that pathway becomes smoother and efficient
Changes in physical structure in response to learning, practice or enviromental influences
LTP may represent biological basis of learning
What are some examples of neuropalsticity?
Jody Miller had right hemisphere removed and within weeks the left had fully compensated
Shows functional plasticity
Gabby Giffords was a victim of gun violence and had aphasia but recovered a lot of it but still has some paralysis
How can the brain be researched?
Autopsy
Case Studies (such as Phineas Gage)
Surgery (lesioning parts of the brain
Scans (such as fMRI’s EEGs)
What does a EEG (Electroencephalograph) do?
Measures electrical activity coming off surface of brain
Can be used to identify epilepsy or sleep disorders
What does an fMRI (Functional Magnetic Resonance Imaging) do?
Shows structure and function
Measures changes in oxygen levels as brain activates/deactivates
What are the first parts of the sleep cycle?
NREM 1 (Non rapid eye movement)
NREM 2
NREM 3
Gets shorter throughout the night
How long is a sleep cycle?
90-120 minutes
What are the last parts of a sleep cycle?
REM (Rapid Eye Movement)
Gets longer throughout the night
At first we go down to deeper stages where our body becomes less responsive
Later in cycle we transition back up to more active stages
What seperates NREM from REM?
Night terrors
Sleepwalking and talking
Essential for the body
According to the memory consoldlidation theory, what part of the sleep cycle is responsible for retaining formation?
REM
What are psychological (mainly Freudian) ideas about dreams?
Sigmund Freud's “The Interpreation of Dreams” 1900
Dreams are road to the unconscious mind filled with content that cannot be faced
Manifest content
Latent Content
What are biological/information processing theories regarding dreams?
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How many hours of sleep does an adult need?
7-9
How many hours of sleep does a child need?
8-10
What contributes to sleep apnea and how can it be cured?
Cessation of breathing
Breathing stops repeatedly
Snoring, Gasping not feeling rested or restored
Types
Obstructive sleep, Central or Complex
Causes
Weight
Smoking
Gender
Age
Etc…
Treatment
Lose weight
Surgery
CPAP
What is narcoplepsy and its cures?
Chronic sleepiness-treatment-medications and support
How do lenses work?
It inverts the image so its projected onto the back of the retina upsidedown
What is the sclera?
shell of the eye
What is the cornea do?
help clean debris off
What does the pupil do?
helps light enter the eye
What does the retina have and what can it do?
Rods, black and white, peripheral vision
What is the anatomy of the outer ear?
Pinna (things you put the back of sunglasses on)
Ear Canal (think of it like a cave)
What is the anatomy of the middle ear?
Ear Drum (tympanic membrane)
Hammer = Malleus
Anvil = Incus
Stirrup = Stapes
What is the anatomy of the inner ear?
Made of cochlea
Size of a pea
Snail shell shaped
Filled with fluid
What are the origins of the corti and cilia?
Cochlea is organ of Corti
Cilia is sticking out of the membrane (each is like a brade of grass)
Frequency at which its stimulated tells nerve to fire at certain things
What is place theory?
HIGH PITCH EXPLANATION
Spatial Coding
When cochlear fluid crashes on place of organ of corti cilia stimulated
Nerve cell attached to cilia sends signal
Brain knows if certain are stimulated and interprets as pitch
What is frequency theory?
LOW PITCH EXPLANATION
Temporal coding
Time is important
Frequency tells brain which pitch to interpret
What’s the most the ear can hear?
Max: amplitude 150 dB (more is pain)
Highest frequency is 20,000 Hz
Whats the least the ear can hear?
amplitude 3-5 dB
Lowest frequency 25 Hz
Do we perceive sound?
No-we sense it
What can cause neurological deafness?
Cochlea is not sending the correct signals
Inherited disease
Over-use of loud noises
Regular long use of normal noises
What can cause conduction deafness?
Something is not functioning in outer or middle ear
Vibrations not making it to the cochlea
Swelling
Blockage
Damage
Do nuerotransmitters have to fit into receptor sites?
Yes-agonists fit into these sites
How does smell work?
Olfaction
Countless molecules float around us and come into our nose
Odorant molecules bind with receptor sites in olfactory neurons
Goes into the olfactory bulb just like the occipital lobe
Bypasses the thalamus which is the router of sensory signals
It goes into the frontal, amygdala, hippocampus, etc…
What are some similarities and differences between olfaction and vision?
Vision | Olfaction |
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