molecular target signals fuck you

alpha1 adrenergic receptor

G protein Coupled Receptor, Metabotropic

Gq coupled

IP3, DAG and Ca2+

Phospholipase C, Protein-Kinase C

beta1 adrenergic receptor

G Protein Coupled Receptor, Metabotropic

Gs coupled

Increase cAMP

Stimulate Adenylyl Cyclase, Protein-Kinase A

beta2 adrenergic receptor

G Protein Coupled Receptor, Metabotropic

Gs coupled

Increase cAMP

Stimulate Adenylyl Cyclase, Protein-Kinase A

m2 muscarinic receptor

G Protein Coupled Receptor, Metabotropic

Gi coupled

Decrease cAMP

Inhibits Adenylyl Cyclase, Inhibits Protein-Kinase An

Nicotinic receptor a1

Ionotropic receptor (ion channels)

Na+/Ca+ in, K+ out

no

no

GABAA receptor

Ionotropic receptor (ion channels)

Cl- in

no

no

Epidermal growth factor receptor

Kinase-linked and related receptor. Receptor tyrosine kinase

Dimerize (clap), autophosphorylation

NO

MAPK pathway (Ras, Raf, Mek, MAPK) activation

Insulin receptor

Kinase-linked and related receptor. Receptor tyrosine kinase

Dimerize (clap), autophosphorylation

NO

P13K/AKT pathway activation

Estrogen receptor

Nuclear receptors

As nuclear receptor, translocates to nucleus, also activates MAPK

no

MAPK pathway

thyroid receptor

Nuclear receptor

In nucleus, with DNA, CoR moves out, CoA moves in

NO

NO

P glycoprotein

transporter atp-binding cassete hydrolosis of ATP no no

Serotonin transporter

transporter solute carrier transporter (slc), exchange no no