Sequence_01_13

The cytoskeleton is the __________ architecture of the cell.

interior

Microtubules are made up of polymers of a protein called __________.

tubulin

Intermediate filaments are made up of a variety of different __________.

proteins

Microfilaments are made up of the protein __________.

actin

In the nucleotide triphosphate bound form, the protein subunits have a __________ affinity for binding to each other.

higher

The addition and removal of subunits in microfilaments occurs at polar ends known as __________ end and __________ end.

plus; minus

The process of new monomers appearing at the filament's front and disappearing at the back is referred to as __________.

treadmilling

The phenomenon of bringing together the first couple of monomers to start forming a filament is called __________.

nucleation

The arp 2/3 complex facilitates the __________ of actin filaments.

nucleation

Cofilin is a protein that facilitates __________ of actin filaments.

depolymerization

The __________ family of GTPases regulates the actin cytoskeleton.

Rho

If all actin is activated by the Rho GTPase, massive bundling of actin into __________ forms.

stress fibers

The actin network can change its stiffness due to a protein called __________.

fimbrin

GTPases regulate the actin dynamics by acting on regulatory proteins, controlling both __________ and __________.

polymerization; depolymerization

Actin filaments are mainly found just beneath the plasma membrane in a structure referred to as __________ actin.

cortical