The Mitochondrial Respiratory Chain and Mitochondrial Disease

What is the ELECTRON TRANSPORT CHAIN (respiratory chain)?

What are the COMPONENTS of the ETC?

Flow of electrons and protons through complexes of the ETC

Path of electrons entering the electron-transfer chain

How is ATP SYNTHESISED?

What is ADENINE NUCLEOTIDE TRANSLOCASE?

What is PHOSPHATE TRANSLOCASE?

What is ATP SYNTHASE?

What is the STRUCTURE of ATP SYNTHASE?

How does the F1 Work - ROTATIONAL CATALYSIS

Summary of function of the Respiratory Chain

Energy yield from oxidation of 1 molecule of glucose

What are UNCOUPLING REAGENTS?

Uncoupling and Brown Fat Thermogenesis

What is Mitochondrial DNA?

Maternal Inheritance

How does AGING affect MITOCHONDRIA?

Mitochondria and Reactive Oxygen Species

Generation of ROS in the mitochondrion

What are MITOCHONDRIAL DISEASES?

Heterogeneity of Mitochondrial Diseases

What is the THRESHOLD EFFECT?

What is Mitochondrial GENETIC BOTTLENECK?

What are MITOCHONDRIAL MYOPATHIES?

Mitochondrial Myopathies caused by MUTATIONS in mtDNA

Mitochondrial Myopathies - TREATMENTS

Mitochondrial Myopathies - PREVENTION

Mitochondrial Gene Replacement (PRONUCLEAR STAGES)

Alternative strategy: Maternal Spindle Transfer

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