p1 spring- NOT DONE

Eptifibatide — Brand

Integrilin

what are antidotes for factor 10 inhibitors (apixabam/rivarox)

Kcentra— prothrombin complexes

Andexanet alfa— andexxa

is primary or secondary hypercholesterolemia the inherited one

primary

• Parents

effect of fenofib/gemfib on hdl, ldl and tgs

hdl: increase

ldl: decrease

tg: decrease

what does acetazolamide do ? indications?

inhibitor carbonic anhydrase, which helps kidneys retain bicarb. means bicarb gets urinated out

• for alkalosis, mountain sickness by causing acidosis so body breathes more

acetazolamide ad eff

hypokalemia, kidney stones (urine more basic), sulfonamide rxns in ppl with allergy

Eptifibatide — Indication

Percutaneous coronary intervention (adjunct); Acute coronary syndrome

Eptifibatide — Adjustment

R

Eptifibatide — Route

IV

Eptifibatide — Boxed Warning

None

Eptifibatide — Contraindications

CVA within 30 days, active abnormal bleeding, surgery/trauma within 6 weeks, severe HTN (SBP >200 mmHg or DBP >110 mmHg), renal dialysis

Eptifibatide — Side Effects

Common: Hypotension, injection site reaction, hemorrhage. Serious: Thrombocytopenia, anaphylaxis, CVA, intracranial hemorrhage.

Eptifibatide — Major DDI

Bleeding risk

Eptifibatide — Other Comments

Alternative IV GP IIb/IIIa inhibitor: abciximab (no longer marketed). :contentReference[oaicite:0]{index=0}

Heparin — Brand

None

Heparin — Indication

ACS; VTE treatment; VTE prophylaxis; Flush to maintain IV patency

Heparin — Adjustment

N

Heparin — Route

IV, Injection

Heparin — Boxed Warning

None

Heparin — Contraindications

Severe thrombocytopenia, history of HIT, uncontrolled active bleeding (except DIC)

Heparin — Side Effects

Common: Thrombocytopenia, increased LFTs. Serious: Bleeding, HIT, hyperkalemia, osteoporosis (long-term use >6 months).

Heparin — Major DDI

Bleeding risk

Heparin — Other Comments

Fatal medication errors—verify concentration and dose. Protamine is the antidote. :contentReference[oaicite:1]{index=1}

Enoxaparin — Brand

Lovenox

Enoxaparin — Indication

ACS; VTE treatment; VTE prophylaxis; Ischemic prophylaxis

Enoxaparin — Adjustment

R

Enoxaparin — Route

Subcutaneous, Injection

Enoxaparin — Boxed Warning

Spinal/epidural hematomas may result in long-term or permanent paralysis.

Enoxaparin (lovenox since LMWHeparin) — Contraindications

Active major bleeding; thrombocytopenia associated with positive enoxaparin antiplatelet antibody; hypersensitivity to heparin, pork products, or benzyl alcohol

Enoxaparin — Side Effects

Common: Anemia, increased LFTs, thrombocytopenia. Serious: Bleeding, pneumonia, hyperkalemia.

Enoxaparin — Major DDI

Bleeding risk

Enoxaparin — Other Comments

More predictable anticoagulant response than UFH; Anti-Factor Xa monitoring usually not required. :contentReference[oaicite:2]{index=2}

Warfarin — Brand

Coumadin, Jantoven

Warfarin — Indication

Anticoagulation

Warfarin — Adjustment

N

Warfarin — Route

PO

Warfarin — Boxed Warning

Fatal bleeding (Vitamin K is the antidote)

Warfarin — Contraindications

Pregnancy (except mechanical heart valves at high embolic risk) or pre-eclampsia, hemorrhagic tendencies, blood dyscrasias, uncontrolled HTN, noncompliance, major surgery

Warfarin — Side Effects

Common: Minor bleeding. Serious: Hemorrhage, skin necrosis, purple toe syndrome.

Warfarin — Major DDI

Bleeding risk; CYP2C9 inhibitors; CYP1A2 inhibitors; CYP3A4 inhibitors; Amiodarone; Bactrim; Metronidazole

Warfarin — Other Comments

Tablet colors: "Please Let George Bush Bring Peaches To Your Wedding" = 1, 2, 2.5, 3, 4, 5, 6, 7.5, 10 mg (pink, lavender, green, brown, blue, peach, teal, yellow, white). Vitamin K is the antidote. :contentReference[oaicite:3]{index=3}

Dabigatran — Brand

Pradaxa

Dabigatran — Indication

DVT/PE treatment and prevention; Nonvalvular A-fib (stroke risk reduction); Thromboprophylaxis

Dabigatran — Adjustment

R

Dabigatran — Route

PO

Dabigatran — Boxed Warning

Premature discontinuation; Spinal/epidural hematoma

Dabigatran — Contraindications

Active bleeding; Mechanical prosthetic heart valves

Dabigatran — Side Effects

Common: Dyspepsia, gastritis-like symptoms, bleeding. Serious: GI bleeding, hemorrhage, increased LFTs, anemia.

Dabigatran (pradexa) — Major DDI

Bleeding risk; P-gp inhibitors

Dabigatran — Other Comments

Prodrug. Do not break, chew, or open capsules. Take with a full glass of water. Idarucizumab (Praxbind) is the antidote. :contentReference[oaicite:4]{index=4}

Argatroban — Brand

None

Argatroban — Indication

HIT; PCI with thrombosis or risk for HIT

Argatroban — Adjustment

H

Argatroban — Route

IV

Argatroban — Boxed Warning

None

Argatroban — Contraindications

Active major bleeding

Argatroban — Side Effects

Common: Bleeding, anemia, hypotension, chest pain, headache, nausea, vomiting, diarrhea, dyspnea, backache, fever. Serious: Hemorrhage, cardiac arrest, sepsis, MI.

Argatroban — Major DDI

Bleeding risk; Warfarin (increased INR)

Argatroban — Other Comments

Increase in INR occurs independent of warfarin use. :contentReference[oaicite:5]{index=5}

Bivalirudin — Brand

Angiomax

Bivalirudin — Indication

PCI with thrombosis

Bivalirudin — Adjustment

R

Bivalirudin — Route

IV

Bivalirudin — Boxed Warning

None

Bivalirudin — Contraindications

Active major bleeding

Bivalirudin — Side Effects

Common: Hypotension, headache, backache. Serious: Ventricular fibrillation, retroperitoneal bleeding, intracranial bleeding, sepsis, cerebral ischemia.

Bivalirudin — Major DDI

Bleeding risk

Bivalirudin — Other Comments

Safe to use in patients with HIT. :contentReference[oaicite:6]{index=6}

Apixaban — Brand

Eliquis

Apixaban — Indication

DVT/PE treatment and prevention; Nonvalvular A-fib (stroke risk reduction)

Apixaban — Adjustment

R

Apixaban — Route

PO

Apixaban — Boxed Warning

Premature discontinuation; Spinal/epidural hematoma

Apixaban — Contraindications

Active bleeding

Apixaban — Side Effects

Common: Bleeding. Serious: GI bleeding, hemorrhage, increased LFTs, anemia.

Apixaban — Major DDI

Bleeding risk; P-gp inhibitors

Apixaban — Other Comments

If patient is ≥80 years, weighs ≤60 kg, or SCr ≥1.5 mg/dL, reduce dose to 2.5 mg BID for nonvalvular A-fib. Avoid grapefruit juice. Andexanet alfa (Andexxa) or 4-factor PCC (Kcentra) are antidotes. Eliquis Starter Pack available. :contentReference[oaicite:7]{index=7}

Rivaroxaban — Brand

Xarelto

Rivaroxaban — Indication

DVT/PE treatment and prevention; Nonvalvular A-fib (stroke risk reduction); Risk reduction of major CV events in CAD/PAD

Rivaroxaban — Adjustment

R

Rivaroxaban — Route

PO

Rivaroxaban — Boxed Warning

Premature discontinuation; Spinal/epidural hematoma

Rivaroxaban — Contraindications

Active bleeding

Rivaroxaban — Side Effects

Common: Bleeding. Serious: GI bleeding, hemorrhage, increased LFTs, anemia, angioedema.

Rivaroxaban — Major DDI

Bleeding risk; P-gp inhibitors

Rivaroxaban — Other Comments

Xarelto

Administer 15 mg and 20 mg tablets with food. Edoxaban is an alternative agent. Andexanet alfa (Andexxa) or 4-factor PCC (Kcentra) are antidotes. :contentReference[oaicite:8]{index=8}

Aspirin — Brand

Bayer Aspirin; Ecotrin

Aspirin — Indication

ACS; Secondary prevention of ASCVD; Ischemic stroke/TIA; Pain; Fever

Aspirin — Adjustment

N

Aspirin — Route

PO, Rectal

Aspirin — Boxed Warning

None

Aspirin — Contraindications

Active bleeding; Bleeding disorders; Severe hypersensitivity to NSAIDs; Children/teenagers with viral infections (Reye syndrome)