Drug Table Week 3

What is the generic name of Atrovent?

Ipratropium Bromide

What is the drug class for Ipratropium Bromide?

Anticholinergic agent

What is the indication for ipratropium bromide?

COPD

What is the major AE for ipratropium bromide?

Dry mouth and throat irritation

What is the mechanism for anticholinergic?

Competitively inhibits ACh @ muscarinic receptors (M3) → Prevents ACh-mediated signaling → Decrease Gq, IP3 → Inhibits intracellular calcium release → Relaxes airway

What is the generic name of Lonhala Magnair or Seebri Neohaler?

Glycopyrrolate

What is the drug class for glycopyrrolate?

Long-acting anti-cholinergic agent (LAMA)

What is the intended use for glycopyrrolate?

COPD

What is the generic name of Spiriva Respimat?

tiotropium

What is the drug class of tiotropium?

Long-acting anti-cholinergic agent (LAMA)

What is the intended use for tiotropium?

COPD

What is the generic name of Ventolin, ProAir?

Albuterol

What is the drug class for albuterol?

beta2-adrenergic agonist

What is the intended use for albuterol? (3)

Asthma, bronchospasm, exercise-induced bronchospasms

What is the generic name of Perforomist?

formoterol

What is the drug class formoterol?

long acting beta2-adrenergic agonist (LABA)

What is the intended use for formoterol?

COPD

What is the drug class for terbutaline?

beta2-adrenergic agonist

What are the two intended use for terbutaline?

asthma and bronchospasms

What is the generic name of Serevent?

salmeterol

What is the drug class for salmeterol?

long acting beta2-adrenergic agonist (LABA)

What are the two intended use for salmeterol?

maintenance for asthma and COPD

What is the generic name of Pulmicort?

budesonide

What is the drug class for budesonide?

Inhaled corticosteroid (ICS)

What are the intended use for budesonide?

Asthma (maintenance)

What is the generic name of Flovent Diskus?

fluticasone

What is the drug class for fluticasone?

Inhaled corticosteroid (ICS)

What are the intended use for fluticasone?

Asthma (maintenance)

What is the generic name of Asmanex HFA?

mometasone

What is the drug class for mometasone?

Inhaled corticosteroid (ICS)

What are the intended use for mometasone?

Asthma (maintenance)

What is the generic name of Combivent?

ipratropium + albuterol

What is the generic name of Bevespi Aerosphere?

formoterol + glycopyrronium

What is the generic name of Symbicort + Breyna?

formoterol + budesonide

What is the generic name of Dulera?

formoterol + mometasone

What is the generic name of Advair + Wixela?

salmeterol + fluticasone

What is the generic name of Humira?

adalimumab

What is the drug class for Humira/ adalimumab?

tumor necrosis factor (TNF) block agent

What is the intended use for Humira/ adalimumab?

rheumatoid arthritis (RA)

What is the generic name of Remicade?

infliximab

What is the drug class for Remicade/infliximab?

tumor necrosis factor (TNF) block agent

What is the intended use for Remicade/infliximab?

rheumatoid arthritis (RA)

What is the generic name of Enbrel?

etanercept

What is the drug class for Enbrel/etanercept?

tumor necrosis factor (TNF) block agent

What is the intended use for Enbrel/etanercept?

rheumatoid arthritis (RA)

What is the MOA for beta2-adrenergic agonist?

Binds to beta2-adrenergic receptors → activate G-proteins → increases cAMP → Activates kinase A → inhibits myosin phosphorylation and ionic calcium levels → increased bronchodilation + airway relaxation

What is the MOA for inhaled corticosteroid?

Binds to inactive glucocorticoid receptor → Activates receptors → Moves into cell nucleus → Turns off transcription of pro-inflammatory genes and turns on anti-inflammatory proteins

What the MOA for tumor necrosis factor (TNF) blocking agent?

Binds to TNF-a → Prevents TNF-a from interacting with receptors → reduced inflammatory cytokines

What is the major AE for tumor necrosis factor (TNF) blocking agent?

Serious infections (tuberculosis)

What is the major AE for inhaled corticosteroid?

Reduced mucus production

What is the major mechanism based AE for beta2-adrenergic agonist?

Blurred vision, dry mouth