Lecture 5/6 - Microbial Genetics, Bacterial Variations, Basic Virology

The bacterial component responsible for drug resistance is

Plasmid

Extrachromosomal element (ECE)

HORIZONTAL GENE TRANSFER

Genotypic variation

▪ Clinical Significance

Introduction to Viruses

Introduction to Viruses continued

Types of Viral Infection

Latent-persistent infection

intermittent episodes of acute Dx, between these episodes there is an absence of detectable infectious virions, e.g. - HSV, VZV.

Chronic-persistent infection:

continued presence of the virus can be detected:

- Dx may be absent, e.g., CMV, HH-6, HBV.

- late immunopathologic Dx, e.g., HBV.

A Journey to Cell

Macromolecular synthesis:

▪ Replication of RNA Genome – RNA virus

Reverse transcriptase: RNA-dependent DNA polymerase

REVERSE TRNASCRIPTASE (RT) ACTIVITY

Prevention/Treatment of Viral Infection

Characteristics - Complex cell wall/Cell membrane

Fungi - Characteristics - Molds:

▪ Molds/Mycelial

Fungi - Characteristics - Yeast:

▪ Fungal Spores

Parasite Definitions

Symbiosis

is a close association of two different organisms

Mutualism

is a beneficial association to both

Commensalism

is a beneficial association for one without effecting the other.

Parasitism

is a beneficial association for one and detrimental for the other

Etiologic agents for 1st exam