endocrine-exam 1 (thyroid pt1)

T4/T3

what does the thyroid produce

metabolism and growth

what does T4/T3 do in teh body

iodine

what does T4/T3 need to function

paraventricular nuclei

what secretes TRH

growth of thyroid gland

what does TSH do in relation of he thyroid gland

13 weeks

when does the secretion of TSH begin

adenylyl cylase

what does TSH bind to

cAMP

what is the second messenger in TSH binding

hypertrophy and hyperplasia

when TSH is increased for long periods of time what occurs to the thyroid follicular cells

increase decrease

________ T4/T3= _______ TSH (negative feedback loop)

TSI

what are antibodies to TSH receptors

increase

when TSI binds to TSH what does it do to the production of T4/T3

80%

how much of the T4 is produced by the thyroid

heart, kidney and liver

where is T4 converted into t3

follicular epithelial cells

what creates T4/T3

ATE ICE

what is the creation of T4/T3 epinim

A

what letter is fo r the active transport of Iodine to follicular cells

sodium-iodine symporter

what transports iodine to follicular cells during ATE ICE

thyroglobulin

what is formed in the follicular ribosem and placed in teh secretory vesicles

follicular lumen

where is thyroglobuline secreted into

colloid

what is thyroiglobulin stored as in the follicular lumen

Iodine oxidation and iodination fo thyroglobulin

what occurs during the I of ATE ICE

MIT and DIT

what makes up T#

DIT and DIT

what make up T4

endocytosis

what occurs during the E of ATE ICE

free T3/T4

what is released during the endocytosis of iodinated thyroglobulin

Wolff-Chaikoff effect

what occurs when Th levels decrease due to an excess iodine ingestion

thyroxine-binding globulin (TBG)

what are non free T4/T3 bound to

free T4/T3

what are active T4/T3

5' deiodinase

what convertes T4 to T3

12 atoms

how many atoms are removed to create T3 from T4

rT3

what is an inactive form of T3 and is created when protecting the thyroid

GH and IGF

what does TH work with it increase bone formation

BMR

what does TH increase to create heat production and oxygen consumption

brain, gonad and spleen

what areas of the body does TH not have an affect on

Na, K and ATPase (sodium potassium pumps)

what does TH increase on teh cellular level during the increase in BMR

CNS

TH are essential for normal maturation of what system

protein synthesis and degradation

TH increase what and what that have opposing affects on each other