2. Databases

GenBank

• the oldest continuously running database containing nucleic acid sequence data.

• supplies source material for R, a database that contains natural (wild-type) sequences. • ) is a database that . • To read a GenBank file it is helpful to know gene structure organization and alternative splicing of transcripts.

Reference Sequence (RefSeq)

contains only wild-type sequences of DNA, RNA, and proteins

Protein Knowledge Database (UniProtKB)

a well-annotated database focused on the protein products of the genes found in GenBank

RefSeq database

information is derived from GenBank records (secondary database b/c it contains information from a primary database)

RefSeq database

more than one record can be generated from a single stretch of DNA

RefSeq database

shows whether more than one RNA molecule can be transcribed from a single DNA region

Entrez

a search engine hosted by NCBI that allows searching several databases simultaneously for certain subjects

Medline

a database that contains science literature and is often accessed through the PubMed portal

Online Median Inheritance of Man (OMIM)

database that describes human genes and disorders associated with genes.to search for human diseases