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Father of toxicology
Paracelsus
Paracelsus is credited with the classic toxicology sounbite:
“ All things are poisons and nothing is without poison ; only the dose makes a thing a poison.
— is considered as the father of modern toxicology.
Mathieu Orfla
Any substance exerting a harmful efect on a living organism
Toxin
Nature of toxins in order from fastest absorption to least:
Gases > Liquids > Solids
What is an example of Synergism
Alcohol + barbiturate
BAL + lead is an example of
Antagonism
Example of two toxins/drugs with addition
Aspirin + Paracetamol
How does stomach acidity effect aspirin toxicity?
High acid → high aspirin toxicity
How does heart disease effect the affect of poisons?
Heart disease → decrease metabolism and excretion by impairing hepatic and renal circulation.