advanced biology test 1

ch 1(done)

Define systems biology

how molecules interact and come together to give rise to subcellular machinery, forming functional units capable of operations that are needed for cell, tissue/organ level phsiological functions

what is a genome

a set of chromosomes

describe genomics

considering genes in the context of the whole genome, providing a understanding of how genes are organized within chromosomes and the whole genome. charaterictics of genes-sequence and single nucleotide polymorphisms, mutations and copy number variations

describe epigenomids

DNA methylation of genes

describe transcriptions

regulations of gene expression and patterns of mRNA expression

what is the top down approach

the description of a system as a whole, Understanding the systems charctericts and capabilites.

• relations are identified via correlation and casual inference is not possible

what is the bottom up apprach

starting with cellular components to develop an understanding of how functional systems such as how subcellular machines are assembles, controlled and operated

what are dynamical models

based on differential equations and can quantitavely estimate how such pathways respond to certain stimuli

what is graph theory

the branch of mathematics that deals with computation of network

what are network models

computable systems and the compuation can provide knowledge of how the system is orginized

• in a network relationship= edges

• entities = nodes

what is big data

large data sets that are terbytes to perabytes large

metabolomics

study of many metabolites in an organism, tissue, or cells

most often liquid chromoatogrphy or mass spec

proteomics

study of many proteins at a time. often less clearly identified with a specific function.

mosty often using mass spec

omics

experimental approach that measures that many individual entities that make a system.

what are the types of stat analysis

• stat corelations between enetities in the same database

• stat corelations between enetities in different database