Erythropoiesis: Formation of Red Blood Cells

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7 Terms

1
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Hematopoietic stem cell (hemocytoblast)

  • Stem cell that gives rise to all formed elements

  • Hormones and growth factors push cell toward specific pathway of blood cell development

  • Committed cells cannot change

  • Transforms into a proerythroblast

<ul><li><p>Stem cell that gives rise to all formed elements</p></li><li><p>Hormones and growth factors push cell toward specific pathway of blood cell development</p></li><li><p>Committed cells cannot change</p></li></ul><p></p><ul><li><p>Transforms into a proerythroblast</p></li></ul><p></p>
2
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Proerythroblast

  • Divides many times; ultimately differentiates into a reticulocyte

  • committed cell

<ul><li><p>Divides many times; ultimately differentiates into a reticulocyte</p></li></ul><p></p><ul><li><p>committed cell</p></li></ul><p></p>
3
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Basophilic erythroblast

Developmental pathway

  • Phase 1: Ribosome synthesis

<p><u>Developmental pathway</u></p><p></p><ul><li><p>Phase 1: Ribosome synthesis</p></li></ul><p></p>
4
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Polychromatic

Developmental pathway

  • Beginning of phase 2

  • Hemoglobin accumulation

  • Nucleus begins to shrink

<p><u>Developmental pathway</u></p><p></p><ul><li><p>Beginning of phase 2</p></li></ul><ul><li><p>Hemoglobin accumulation</p></li><li><p>Nucleus begins to shrink</p></li></ul><p></p>
5
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Orthochromatic erythroblasts

Developmental pathway

  • Midpoint and end of phase 2

  • increased Hemoglobin accumulation

  • Nucleus continues to shrink and eventually gets ejected

<p><u>Developmental pathway</u></p><p></p><ul><li><p>Midpoint and end of phase 2</p></li></ul><ul><li><p>increased Hemoglobin accumulation</p></li><li><p>Nucleus continues to shrink and eventually gets ejected</p></li></ul><p></p>
6
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Reticulocyte

Developmental pathway

  • Beginning of phase 3

  • only contains some ribosomes

  • becomes mature RBC

<p><u>Developmental pathway</u></p><p></p><ul><li><p>Beginning of phase 3</p></li><li><p><span>only contains some ribosomes</span></p></li><li><p><span>becomes mature RBC</span></p></li></ul><p></p>
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Erythrocyte

Developmental pathway

  • mature RBC

  • The ribosomes degrade

  • anucleate, cannot synthesize new proteins, grow or divide

  • Life span about 120 days

<p><u>Developmental pathway</u></p><p></p><ul><li><p><span>mature RBC</span></p></li><li><p><span>The ribosomes degrade</span></p></li><li><p><span>anucleate, cannot synthesize new proteins, grow or divide</span></p></li><li><p><span>Life span about 120 days</span></p></li></ul><p></p>