Vibrio

Gram

negative

Motility?

motile

Growing conditions

Halophile (high salt), facultative anaerobe, aquatic environment

Transmission?

fecal-oral

Disease?

cholera

Cholera symptoms

nausea, diarrhea, dehydration

Biggest issue of symptoms

dehydration

Cholera epidemic

infects all ages

cholera endemic

infects children between 2-15 years old

Cholera treatment?

rehydration

Virulence factors?

flagella, cholera toxin (CTX), toxin-coregulated pilus

V. vulnificus virulence factors

cytolysin labile toxin, phospholipase A2 (PlpA)

What is PlpA ?

exotoxin that causes necrotic cell death

Where is V. vulnificus most common in the US?

coastal states

How does V. vulnificus infect?

ingestion or wound

How many deaths does V. vulnificus cause due to seafood?

95%

Treatment of V. vulnificus?

cephalosprin plus doxy, debride wound infections

How does V. parahaemolyticus infect?

ingestion or wound

V. vulnificus growth?

Intracellular

V. vulnificus secretion system?

2 T3SS

V. vulnificus treatment?

supportive care, doxy/cefotaxime