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water account for what amt of body weight
1/3
which age is more hydrated
younger
gender and hydration
men have more muscle, so more water
fat’s water content
20%
skeletal muscle’s water content
75%
intracellular fluid
fluid found within cells (2/3 of water in body)
extracellular fluid
fluid outside cells (1/3 of water in body)
interstitial fluid
fluid between cells
electrolytes
things that separate into ions in water (conduct electricity)
nonelectrolytes
substances that don’t separate into ions in water
intracellular vs extracellular fluid
intracellular is higher in K+; extracellular is higher in Na+
intracellular and interstitial fluids are higher in
protein
how much water should be taken in & eliminated in a day
2500mL
thirst mechanism
dry mouth and excitation of thirst centers
how much water is lost through urine every day
500mL
triggers of ADH
low ECF concentration, low BP, low blood volume
disorders of water balance (3)
dehydration, hypotonic hydration, edema
dehydration
body is in negative fluid balance
dehydration causes
hemorrhage, burns, vomiting, diarrhea, diabetes
dehydration symptoms
dry mouth, thirst, dry flushed skin, oliguria
hypotonic hydration
cellular overhydration due to drinking excess water
hyponaturemia
salt become dilute even though there ie enough in body
hypotonic hydration symptoms
nausea, vomiting, cramping, cerebral edema
hypotonic hydration treatments
Mannitol and hypertonic saline
edema
accumulation of fluid in interstitial space (tissue swelling)
edema cause
increase in capillary blood pressure
salts
maintains proper neuron and muscle cell function
sodium
regulates ECF
sodium regulation (3)
Aldosterone, Atrial Natriuretic peptide, estrogen
aldosterone
increases sodium reabsorption in tubule and collecting duct
what causes release of aldosterone
increase in potassium or presence of Angiotensin II causes adrenal cortex to release
atrial natriuretic peptide (ANP)
inhibits release of renin, ADH, aldosterone (causes vasodilation)
estrogen
increases salt reabsorption
hyperkalemia
increase in potassium (K+) in ECF
hypokalemia
decrease in potassium (K+) in ECF
what organ is sensitive to K+ level changes
heart
calcium function
neuromuscular function
hypocalcemia
increases excitability and causes tetany
hypercalcemia
inhibits neurons and muscle cells; causes cardiac arrythmia
parathyroid hormone (PTH)
released when blood levels of calcium are low
PTH increases (3)
bone breakdown, calcium absorption
regulating pH (3)
chemical buffers, brain stem respiratory centers, renal mechanisms
phosphate buffer system function
important in urine and intracellular fluid where phosphate levels are higher
protein buffer system
regulates pH by releasing hydrogen
respiratory acidosis
impaired gas exchange
respiratory alkalosis
hyperventilation causes too much carbon dioxide to be removed
metabolic acidosis
low pH and bicarbonate ions
metabolic alkalosis
high pH (excessive vomiting)
acidosis effects
coma or death
alkalosis effects
nervousness, convulsions, respiratory arrest