Noradrenergic Sympathomimetic Anorexiants,

What is the primary use of Phentermine hydrochloride?

Short-term weight loss in combination with diet and exercise in people with obesity.

What therapeutic class does Phentermine belong to?

Weight management agent and anorexiant.

What is the pharmacologic class of Phentermine?

CNS stimulant and sympathomimetic amine.

How does Phentermine act on the central nervous system?

It inhibits the reuptake of norepinephrine and serotonin, stimulating the hypothalamic satiety center to suppress appetite.

What are the indications for Phentermine use?

Short-term treatment of obesity for patients with BMI ≥ 30 or ≥ 27 with comorbidities.

What is the absorption profile of Phentermine?

Well absorbed orally.

What is the half-life of Phentermine?

Approximately 20 hours.

What are some contraindications for using Phentermine?

Moderate to severe hypertension, cardiovascular disease, hyperthyroidism, glaucoma, pregnancy or breastfeeding, drug abuse history, and within 14 days of MAOI use.

What is the Black Box Warning for Phentermine?

While there is no formal FDA Black Box Warning, there are serious cardiovascular risks and addiction potential which require close monitoring.

What are some common adverse effects of Phentermine?

Nervousness, palpitations, tachycardia, systemic hypertension, dry mouth, constipation, insomnia, and tolerance may develop.

What dosage forms are available for Phentermine?

Immediate-release and orally disintegrating tablets.

What special considerations should be taken for older adults when administering Phentermine?

Use cautiously due to increased adverse risk from comorbidities.

Is Phentermine safe for use during pregnancy?

No, it is not safe in pregnancy.

What can increase the effects of Phentermine?

TCAs, linezolid, alcohol, CNS stimulants, and other sympathomimetics.

What nursing considerations should be kept in mind before administering Phentermine?

Give before meals, do not chew or crush sustained-release forms, and ensure the last dose is taken at least 6 hours before bedtime.

What is the goal for weight loss when taking Phentermine?

1–2 pounds per week.

How long is Phentermine advised for use?

Short-term, usually up to 12 weeks.

What are the risks associated with other anorexiant drugs in the same class as Phentermine?

CV side effects like increased heart rate and blood pressure, CNS effects like insomnia and nervousness, gastrointestinal side effects, and dependence.

What should patients monitor when taking Phentermine?

Blood pressure regularly and be aware of potential for drowsiness.

What is the maximum daily dosage for the immediate-release form of Phentermine?

37.5 mg daily or divided.

What effect does Phentermine have on appetite?

It suppresses appetite.

How does Phentermine help patients with obesity?

By stimulating norepinephrine and serotonin release, leading to appetite suppression.

What adverse effects are specific to the cardiovascular system when using Phentermine?

Palpitations and systemic hypertension.

What metabolic effect can Phentermine cause?

Increasing sympathetic nervous system activity affecting glucose regulation and insulin sensitivity.

How long after starting Phentermine might tolerance develop?

In approximately 4–6 weeks.

Which patients should Phentermine be cautioned against?

Those with a history of substance abuse, cardiovascular disease, and hypertension.

What is a special note regarding Diethylpropion?

It is chemically similar to bupropion and may help reduce cravings.

Which drug in the same class as Phentermine also contains topiramate?

Phentermine-Topiramate (Qsymia).

What are patients advised to avoid while taking Phentermine?

Caffeine and alcohol.

When is the ideal time for patients to take Phentermine?

In the morning, before breakfast.