Disrupting the adaptive immune system

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What are some pathogen strategies to avoid or disrupt the adaptive immune response?

Pathogen strategies include subverting MHC class I presentation, blocking lymphocyte activation or effector mechanisms, and degrading IgA at mucosal surfaces.

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How does cytomegalovirus disrupt the adaptive immune response?

Cytomegalovirus subverts MHC class I presentation, preventing proper antigen presentation to cytotoxic T cells.

3
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How do Helicobacter pylori and Neisseria gonorrhoeae interfere with the adaptive immune response?

They block lymphocyte activation or effector mechanisms, preventing effective immune responses.

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How do Staphylococcus, Haemophilus influenzae, and Neisseria disrupt mucosal immunity?

These bacteria degrade IgA at mucosal surfaces using an enzyme, preventing IgA-mediated neutralization of pathogens.