Hospital IPPE Top Drugs #1

What is the brand name(s) for Alteplase? (HIGH-ALERT DRUG)

Activase

What is the generic name for Activase? (HIGH-ALERT DRUG)

Alteplase

What drug class is Alteplase (Activase) in? (HIGH-ALERT DRUG)

Thrombolytic — General category: Cardiovascular

What is/are the indication(s) for Alteplase (Activase)? (HIGH-ALERT DRUG)

Acute ischemic stroke; myocardial infarction, pulmonary embolism

What is the common dose/dosing range for Alteplase (Activase)? (HIGH-ALERT DRUG)

Acute ischemic stroke: 0.9 mg/kg, not exceed 90 mg; 10% of total dose administered IV bolus over 1 minute, infusion of the remainder total dose over 60 minutes

What are the key safety concerns (precautions/black box warnings) for Alteplase (Activase)? (HIGH-ALERT DRUG)

Intracranial hemorrhage, subarachnoid hemorrhage, internal bleeding | Stroke within last 3 months, serious head trauma within last 3 months, current severe uncontrolled hypertension

Is Alteplase (Activase) considered a high-alert medication?

Yes — Alteplase (Activase) is a high-alert medication.

What route(s) of administration are used for Alteplase (Activase)? (HIGH-ALERT DRUG)

Parenteral

What is the brand name(s) for Amiodarone? (HIGH-ALERT DRUG)

Cordarone

What is the generic name for Cordarone? (HIGH-ALERT DRUG)

Amiodarone

What drug class is Amiodarone (Cordarone) in? (HIGH-ALERT DRUG)

Antiarrhythmic — General category: Cardiovascular

What is/are the indication(s) for Amiodarone (Cordarone)? (HIGH-ALERT DRUG)

Heart rhythm disorders (ventricular tachycardia or fibrillation)

What is the common dose/dosing range for Amiodarone (Cordarone)? (HIGH-ALERT DRUG)

Load dose: 800 - 1600 mg daily x 1-3 weeks; then, 600 - 800 mg daily x 1 month; Maintenance dose: 400 mg daily

What are the key safety concerns (precautions/black box warnings) for Amiodarone (Cordarone)? (HIGH-ALERT DRUG)

Pulmonary toxicity (pneumonitis), hepatotoxicity, heart block | Thyrotoxicosis, optic neuropathy/neuritis

Is Amiodarone (Cordarone) considered a high-alert medication?

Yes — Amiodarone (Cordarone) is a high-alert medication.

What route(s) of administration are used for Amiodarone (Cordarone)? (HIGH-ALERT DRUG)

Parenteral, Oral

What is the brand name(s) for Apixaban? (HIGH-ALERT DRUG)

Eliquis

What is the generic name for Eliquis? (HIGH-ALERT DRUG)

Apixaban

What drug class is Apixaban (Eliquis) in? (HIGH-ALERT DRUG)

Anticoagulant - Factor Xa inhibitor — General category: Cardiovascular

What is/are the indication(s) for Apixaban (Eliquis)? (HIGH-ALERT DRUG)

Thromboembolism treatment & prevention, stroke prevention

What is the common dose/dosing range for Apixaban (Eliquis)? (HIGH-ALERT DRUG)

VTE treatment: 10 mg PO BID x 7d, then 5mg BID; VTE prevention: 2.5 mg PO BID; Stroke prevention in nonvalvular a-fib: 5 mg PO BID

What are the key safety concerns (precautions/black box warnings) for Apixaban (Eliquis)? (HIGH-ALERT DRUG)

Thrombotic events after premature discontinuation | Bleeding

Is Apixaban (Eliquis) considered a high-alert medication?

Yes — Apixaban (Eliquis) is a high-alert medication.

What route(s) of administration are used for Apixaban (Eliquis)? (HIGH-ALERT DRUG)

Oral

What is the brand name(s) for Atropine?

Atropen

What is the generic name for Atropen?

Atropine

What drug class is Atropine (Atropen) in?

Muscarinic antagonist — General category: Cardiovascular

What is/are the indication(s) for Atropine (Atropen)?

Bradycardia (advanced cardiac life support)

What are the key safety concerns (precautions/black box warnings) for Atropine (Atropen)?

Narrow-angle glaucoma | Myasthenia gravis

What route(s) of administration are used for Atropine (Atropen)?

Parenteral

What is the brand name(s) for Bumetanide?

Bumex

What is the generic name for Bumex?

Bumetanide

What drug class is Bumetanide (Bumex) in?

Diuretic - Loop — General category: Cardiovascular

What is/are the indication(s) for Bumetanide (Bumex)?

Edema

What is the common dose/dosing range for Bumetanide (Bumex)?

0.5 - 2 mg IV/IM or PO daily; 1:40 ratio of Bumex: Lasix dose

What are the key safety concerns (precautions/black box warnings) for Bumetanide (Bumex)?

Hypokalemia | Profound diuresis, electrolyte loss, dehyration and acute renal failure with excessive amounts

What route(s) of administration are used for Bumetanide (Bumex)?

Parenteral, Oral

What is the brand name(s) for Clopidogrel?

Plavix

What is the generic name for Plavix?

Clopidogrel

What drug class is Clopidogrel (Plavix) in?

Antiplatelet — General category: Cardiovascular

What is/are the indication(s) for Clopidogrel (Plavix)?

Acute coronary syndromes, MI and stroke prevention

What is the common dose/dosing range for Clopidogrel (Plavix)?

Load: 300 mg PO x 1 dose; Maintenance: 75 mg PO daily

What are the key safety concerns (precautions/black box warnings) for Clopidogrel (Plavix)?

Diminished antiplatelet activity in patients who are CPY2C19 poor metabolizers

What route(s) of administration are used for Clopidogrel (Plavix)?

Oral

What is the brand name(s) for Dabigatran? (HIGH-ALERT DRUG)

Pradaxa

What is the generic name for Pradaxa? (HIGH-ALERT DRUG)

Dabigatran

What drug class is Dabigatran (Pradaxa) in? (HIGH-ALERT DRUG)

Anticoagulant - Direct thrombin inhibitor — General category: Cardiovascular

What is/are the indication(s) for Dabigatran (Pradaxa)? (HIGH-ALERT DRUG)

Thromboembolism treatment & prevention, stroke prevention

What is the common dose/dosing range for Dabigatran (Pradaxa)? (HIGH-ALERT DRUG)

150 mg PO BID

What are the key safety concerns (precautions/black box warnings) for Dabigatran (Pradaxa)? (HIGH-ALERT DRUG)

Thrombotic events after premature discontinuation | Bleeding

Is Dabigatran (Pradaxa) considered a high-alert medication?

Yes — Dabigatran (Pradaxa) is a high-alert medication.

What route(s) of administration are used for Dabigatran (Pradaxa)? (HIGH-ALERT DRUG)

Oral

What is the brand name(s) for Digoxin? (HIGH-ALERT DRUG)

Lanoxin (IV), Digitek (PO)

What is the generic name for Lanoxin (IV), Digitek (PO)? (HIGH-ALERT DRUG)

Digoxin

What drug class is Digoxin (Lanoxin (IV), Digitek (PO)) in? (HIGH-ALERT DRUG)

Cardiac glycoside — General category: Cardiovascular

What is/are the indication(s) for Digoxin (Lanoxin (IV), Digitek (PO))? (HIGH-ALERT DRUG)

Heart failure (inotrope); atrial fibrillation (rate controller)

What is the common dose/dosing range for Digoxin (Lanoxin (IV), Digitek (PO))? (HIGH-ALERT DRUG)

Heart failure: 0.125-0.25 mg PO/IV qDay

What are the key safety concerns (precautions/black box warnings) for Digoxin (Lanoxin (IV), Digitek (PO))? (HIGH-ALERT DRUG)

Sinus bradycardia

Is Digoxin (Lanoxin (IV), Digitek (PO)) considered a high-alert medication?

Yes — Digoxin (Lanoxin (IV), Digitek (PO)) is a high-alert medication.

What route(s) of administration are used for Digoxin (Lanoxin (IV), Digitek (PO))? (HIGH-ALERT DRUG)

Parenteral, Oral

What is the brand name(s) for Diltiazem?

Cardizem, Tiazac

What is the generic name for Cardizem, Tiazac?

Diltiazem

What drug class is Diltiazem (Cardizem, Tiazac) in?

Calcium channel blocker — General category: Cardiovascular

What is/are the indication(s) for Diltiazem (Cardizem, Tiazac)?

Atrial fibrillation (rate controller), angina, hypertension

What is the common dose/dosing range for Diltiazem (Cardizem, Tiazac)?

Load: 30 mg Q6H; Maintence: 180 - 260 mg/day

What are the key safety concerns (precautions/black box warnings) for Diltiazem (Cardizem, Tiazac)?

Bradycardia (heart rate <45 bpm); Second- or third-degree heart block | Severe hypotension

What route(s) of administration are used for Diltiazem (Cardizem, Tiazac)?

Parenteral, Oral

What is the brand name(s) for Dobutamine? (HIGH-ALERT DRUG)

Dobutrex

What is the generic name for Dobutrex? (HIGH-ALERT DRUG)

Dobutamine

What drug class is Dobutamine (Dobutrex) in? (HIGH-ALERT DRUG)

Inotrope - Beta-adrenergic agonist — General category: Cardiovascular

What is/are the indication(s) for Dobutamine (Dobutrex)? (HIGH-ALERT DRUG)

Cardiac decompensation

What is the common dose/dosing range for Dobutamine (Dobutrex)? (HIGH-ALERT DRUG)

2.5-20 mcg/kg/min; Max: 40 mcg/kg/min

What are the key safety concerns (precautions/black box warnings) for Dobutamine (Dobutrex)? (HIGH-ALERT DRUG)

Idiopathic hypertrophic subaortic stenosis

Is Dobutamine (Dobutrex) considered a high-alert medication?

Yes — Dobutamine (Dobutrex) is a high-alert medication.

What route(s) of administration are used for Dobutamine (Dobutrex)? (HIGH-ALERT DRUG)

Parenteral

What is the brand name(s) for Dopamine? (HIGH-ALERT DRUG)

Dopastat, Intropin

What is the generic name for Dopastat, Intropin? (HIGH-ALERT DRUG)

Dopamine

What drug class is Dopamine (Dopastat, Intropin) in? (HIGH-ALERT DRUG)

Inotrope - Sympathomimetic amine — General category: Cardiovascular

What is/are the indication(s) for Dopamine (Dopastat, Intropin)? (HIGH-ALERT DRUG)

Cardiovascular shock

What is the common dose/dosing range for Dopamine (Dopastat, Intropin)? (HIGH-ALERT DRUG)

1-5 mcg/kg/min; Max: 20 mcg/kg/min

What are the key safety concerns (precautions/black box warnings) for Dopamine (Dopastat, Intropin)? (HIGH-ALERT DRUG)

Pheochromocytoma | Ventricular fibrillation

Is Dopamine (Dopastat, Intropin) considered a high-alert medication?

Yes — Dopamine (Dopastat, Intropin) is a high-alert medication.

What route(s) of administration are used for Dopamine (Dopastat, Intropin)? (HIGH-ALERT DRUG)

Parenteral

What is the brand name(s) for Enoxaparin? (HIGH-ALERT DRUG)

Lovenox

What is the generic name for Lovenox? (HIGH-ALERT DRUG)

Enoxaparin

What drug class is Enoxaparin (Lovenox) in? (HIGH-ALERT DRUG)

Low molecular weight heparin — General category: Cardiovascular

What is/are the indication(s) for Enoxaparin (Lovenox)? (HIGH-ALERT DRUG)

Thromboembolism treatment & prevention, myocardial infarction

What is the common dose/dosing range for Enoxaparin (Lovenox)? (HIGH-ALERT DRUG)

Treatment: 1mg/kg SQ Q12H or 1.5mg/kg SQ daily; Prophylaxis: 30mg SQ Q12H or 40mg SQ daily. Renal dose adjustment: treatment - 1mg/kg SQ daily; prophylaxis: 30mg SQ daily

What are the key safety concerns (precautions/black box warnings) for Enoxaparin (Lovenox)? (HIGH-ALERT DRUG)

Thrombocytopenia or active bleeding | Bleeding

Is Enoxaparin (Lovenox) considered a high-alert medication?

Yes — Enoxaparin (Lovenox) is a high-alert medication.

What route(s) of administration are used for Enoxaparin (Lovenox)? (HIGH-ALERT DRUG)

Parenteral

What is the brand name(s) for Furosemide?

Lasix

What is the generic name for Lasix?

Furosemide

What drug class is Furosemide (Lasix) in?

Loop diuretic — General category: Cardiovascular

What is/are the indication(s) for Furosemide (Lasix)?

Edema

What is the common dose/dosing range for Furosemide (Lasix)?

20-80mg/dose for edema, 40mg BID hypertension

What are the key safety concerns (precautions/black box warnings) for Furosemide (Lasix)?

Hypokalemia | Profound diuresis, electrolyte loss, dehyration and acute renal failure with excessive amounts

What route(s) of administration are used for Furosemide (Lasix)?

Parenteral, Oral

What drug class is Heparin () in? (HIGH-ALERT DRUG)

Anticoagulant — General category: Cardiovascular

What is/are the indication(s) for Heparin ()? (HIGH-ALERT DRUG)

Thromboembolism treatment & prevention, myocardial infarction