1-non-random mating

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4 Terms

1
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3 aspects of genetic variation

  1. Number of alleles at a locus

    • Short nucleotide polymorphisms = 2

    • Microsatellites = many

  2. Frequency of each genotype at the locus in the population

  3. Frequency of alleles at the locus in the population

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What are the hardy Weinberg assumptions

  1. Mating is random

  2. Population size is finite (or very large)

    • Small changes dont affect

  3. No mutations

  4. No natural selection

    • Neither of the alleles have a greater chance of selection

  5. No migration

    • New alleles aren’t introduced in the population

  6. Allele frequencies are the same in males and females

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Heterozygosity and frequency statistics

  • Hs = average of within subpopulations expected HWE heterozygosity

  • Ht = expected (HWE) heterozygosity of the total population

  • FST (fixation index) = overall reduction in average heterozygosity compared to heterozygosity of total population

<ul><li><p>Hs = average of <span style="color: blue">within </span>subpopulations expected HWE heterozygosity</p></li><li><p>Ht = expected (HWE) heterozygosity of the <span style="color: blue">total </span>population </p></li><li><p>FST (fixation index) = overall reduction in average heterozygosity compared to heterozygosity of total population </p></li></ul>
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Do HWE assumptions apply in real life

No

  • Due to evolution - changes in allele frequencies over time