Neoplasm - Metastatic Carcinoma

Primary or Secondary?

Secondary

MC location in female to appear?

Breast

MC location in male to appear?

Prostate

MC pathway?

Hematogenous

What vessel does metastatic carcinoma travel through most commonly?

Batson’s Venous Plexus

Why are secondary tumors more common in the axial skeleton/spine?

Due to Batson’s Venous Plexus

Metastatic carcinoma is mostly ______ in nature.

Lytic

What is one the indicators that presents at night?

Deep bone pain

How much bone loss that is visible on x-ray?

30 - 50%

Elevated alkaline phosphatase indicative of?

Blastic Metastasis

Elevated Acid Phosphatase indicative of?

Prostate Metastasis

What are the name signs associated with metastatic carcinoma? (4, IP.WB)

1. Ivory Vertebra

2. Pathological Fractures

   • Vertebra Plana

   • Universal Compression Fracture

   • Pancake Verterbra

3. Winking Owl Sign

4. Blind Own Sign

What is affected with winking and blind owl signs?

Pedicles

With lab results what levels are elevated?

1. ESR

2. Alkaline Phosphatase

3. Acid Phosphatase

What is levels are normal that is found in metastatic carcinoma?

Ca2+