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Protic Solvent
Contains O-H and N-H bonds, can provide protons
Aprotic Solvent
Cannot provide protons, has no O-H and N-H bonds
Sn2 Nu/Base
Good nucleophile
Sn1 Nu/Base
Bad nucleophile
E2 Nu/Base
Strong base
E1 Nu/Base
Weak base
Sn2 Substrate
Methane, Primary, Secondary
Sn1 and E1 Substrate
Secondary, Tertiary
E2 Substrate
Primary, Secondary, Tertiary
Sn2 and E2 Solvent
Aprotic
Sn1 and E1 Solvent
Protic
Nu/Base trend for protic solvents
I>Br>Cl>F
Nu/Base trend for aprotic solvents
F>Cl>Br>I