Rhumetoid Arthritis

What is RA

Chronic autoimmune disorder that presents as a inflammatory disorder

What sides of the body does RA targer

Both sides/ Bilateral

What is autoimmunity

When the body begins to produce immune cells/antibodies at antigen within host . Loss of self tolerance

What population is autoimmune diseases common

Women and childbearing aged women

What genetic markers are present in RA

HLA

C reactive

Anticitulline

Rhumetoid Factor

Antinuclear antibody

Explain role of CRP in RA

CRP activates complement system which kills bacteria and other cells and increases in RA also leads to bone resorption and other diseases

Explain the role if Anticitrullinated Antibodies

Arg converts to Citrullene and then appear as foreign to immune system leading them to become antigens. This presence of AC antibody is good for diagnosis

What is the primary target in the joint for RA

Synovial Membrane

What are the 3 phases of progression of RA

1. Intiation- Nonspecific Inflammation

2. - T-Lymphocyte activation

3. Chronic Inflmation- Tissue injured, Interluekins trigger

What is the mass that forms on the synovial space of membrane called

Pannus

What are the effects of RA on the skin

Subcutaneous Rhumetoid Nodules and Vasculitis

What are the effects of RA on lungs

Lung Fibrosis

Caplan’s Syndrome

What is Caplan’s Syndrome

Lung Nodule and exposure to coal dust causes this

What are the effects of RA on the heart and blood vessel

Risk of artherosclerosis

Risk of Myocardial infarction and stroke

What is the effects of RA on the blood

Anemia

Low WBC

Increased Platelets

What phase reactant is CRP

Acute Phase reactant

When does CRP increase

In response to inflammation by Il6

What does CRP activate

The complement system 

What levels of CRP indicate RA

High levels and the higher the levels the more severe

What does CRP have to do with osteoclasts

Influences Osteoclast activity leading to bone resorption

What protein do Macrophages citrullenate

Vimentin

What is Rhumetoid Factor directed against

Antibody against Fc portion of IGG antibody

What is rhumetoid factor

Autoantibody found in RA and a marker for RA

What is intiation Phase of RA

Inflammation that is nonspecific

What is teh Amplication phase

T lymphocyte activation

What is the Chronic Inflammatory Phase

Tissue is injured by triggering of cytokines