PARASYMPATHETIC NERVOUS SYSTEM

Neurotransmitter

Acetylcholine (Ach)

Cholinergic

Responding to acetylcholine, refers to receptor sites stimulated by Ach as well as neurons that releasing acetylcholine.

Cholinergic receptor

Receptor sites on effectors that respond to acetylcholine.

Other term for Cholinergic receptor

Cholinoreceptors

Muscarinic receptors

A G-Protein linked receptors

Muscarinic receptors

Contains seven transmembrane domain whose 3rd cytoplasmic loop is coupled to G-protein that function as “intramembrane transducers”

Muscarinic receptors

Regulates the production of intracellular second messengers

Muscarinic receptors

Determines agonist selectivity

Nicotinic receptors

Ion-Channels (Ionotropic Receptors)

Nicotinic receptors

Part of transmembrane polypeptide whose subunits form cation-selective ion channels

Hemicholiniums

Inhibits choline transportation from the extracellular fluid into the neuron terminal