Enzyme Control and Feedback Mechanisms

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30 Terms

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Enzyme

Protein that catalyzes biochemical reactions.

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Temperature Effect

Higher temperature increases molecular collisions.

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Denaturation

Loss of enzyme structure due to extreme conditions.

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pH Impact

Affects charge of amino acids in enzymes.

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Competitive Inhibitors

Resemble substrate, bind to active site.

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Km

Michaelis constant, indicates substrate affinity.

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Vmax

Maximum reaction rate of an enzyme.

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AZT

Competitive inhibitor for reverse transcriptase in HIV.

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Transition State Analogues

Mimic transition state for enzyme inhibition.

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Oseltamivir

Blocks neuraminidase, used against influenza.

<p>Blocks neuraminidase, used against influenza.</p>
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Catalytic Antibodies

Antibodies that mimic enzyme active sites.

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Non-competitive Inhibitors

Bind elsewhere, do not affect Km.

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Irreversible Inhibitors

Covalently bind, permanently inactivate enzymes.

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Feedback Inhibition

End product inhibits earlier pathway enzymes.

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Allosteric Enzymes

Change shape upon effector binding, altering activity.

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Allosteric Effectors

Metabolites that modulate enzyme activity non-covalently.

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Sigmoidal Kinetics

Characteristic curve of allosteric enzyme activity.

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Concerted Model

All subunits change conformation simultaneously.

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Sequential Model

Binding induces conformational changes in subunits.

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Covalent Modification

Regulation via reversible chemical changes.

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Phosphorylation

Addition of phosphate groups to regulate enzymes.

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Proproteins

Inactive precursors activated by proteolytic cleavage.

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Zymogens

Inactive digestive enzymes activated by cleavage.

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Protein Kinases

Enzymes that add phosphate groups.

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Protein Phosphatases

Enzymes that remove phosphate groups.

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Regulatory Enzymes

Key enzymes controlling metabolic pathways.

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Active Site

Region where substrate binds on enzyme.

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Biochemical Pathways

Series of reactions catalyzed by enzymes.

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M-M Kinetics

Michaelis-Menten kinetics describe enzyme activity.

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Substrate Concentration

Influences reaction rate and enzyme activity.