Module 7 - Endocrine Drugs

somatropin MOA

mimics growth hormone

somatropin adverse effects

hyperglycemia, hypothyroidism, hypercalciuria, antibodies to growth hormone, flu like symptoms

somatropin contraindications

children with closed growth plates, patients with tumors, patients with acute illness

somatropin interactions

glucocorticoids

octreotide (Sandostatin) MOA

antagonized effects of growth hormone

octreotide uses

carcinoid tumors, VIPoma (causes severe diarrhea, flushing, and hypotension), esophageal varices

octreotide adverse effects

blood glucose fluctuations, N/V/D, conduction abnormalities, gallbladder impairment

desmopressin (DDAVP) MOA

mimics action of ADH

desmopressin uses

diabetes insipidus (low ADH - polydipsia, polyuria, dehydration), GI bleed, hemophilia and von Willebrand

desmopressin med admin

IV, IM, SUBQ, IN (each spray 10mg, alternate nostrils)

symptoms of hypothyroidism

cold intolerance, weight gain, depression, brittle hair and nails, fatigue

symptoms of hyperthyroidism

diarrhea, flushing, increased appetite, muscle weakness, fatigue, irritability, nervousness, sleep disorders, heat intolerance, altered menstrual flow

thyroid replacement drugs

levothyroxine (Synthroid), desiccated thyroid

patient teaching levothyroxine

take on an empty stomach early in the morning, do not switch products without talking to a provider

thyroid replacement drugs are pregnancy category

A

antithyroid drugs

propylthiouracil (PTU), methimazole

antithyroid drugs adverse effects

liver toxicity, bone marrow toxicity, agranulocytosis, leukopenia, thrombocytopenia, nephritis, enlarged thyroid gland

antithyroid medications are pregnancy class

D (thyroidectomy is best option during pregnancy)

antithyroid patient education

takes 2 weeks for symptom improvement, avoid sources of iodine (iodized salt, tofu, soy, seafood, breads), report s/s of liver and bone marrow toxicity (fever, sore throat, skin eruptions, bleeding/bruising)