Module 7 - Endocrine Drugs

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somatropin MOA

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1

somatropin MOA

mimics growth hormone

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2

somatropin adverse effects

hyperglycemia, hypothyroidism, hypercalciuria, antibodies to growth hormone, flu like symptoms

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3

somatropin contraindications

children with closed growth plates, patients with tumors, patients with acute illness

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4

somatropin interactions

glucocorticoids

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5

octreotide (Sandostatin) MOA

antagonized effects of growth hormone

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6

octreotide uses

carcinoid tumors, VIPoma (causes severe diarrhea, flushing, and hypotension), esophageal varices

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7

octreotide adverse effects

blood glucose fluctuations, N/V/D, conduction abnormalities, gallbladder impairment

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8

desmopressin (DDAVP) MOA

mimics action of ADH

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9

desmopressin uses

diabetes insipidus (low ADH - polydipsia, polyuria, dehydration), GI bleed, hemophilia and von Willebrand

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10

desmopressin med admin

IV, IM, SUBQ, IN (each spray 10mg, alternate nostrils)

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11

symptoms of hypothyroidism

cold intolerance, weight gain, depression, brittle hair and nails, fatigue

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12

symptoms of hyperthyroidism

diarrhea, flushing, increased appetite, muscle weakness, fatigue, irritability, nervousness, sleep disorders, heat intolerance, altered menstrual flow

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13

thyroid replacement drugs

levothyroxine (Synthroid), desiccated thyroid

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14

patient teaching levothyroxine

take on an empty stomach early in the morning, do not switch products without talking to a provider

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15

thyroid replacement drugs are pregnancy category

A

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16

antithyroid drugs

propylthiouracil (PTU), methimazole

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17

antithyroid drugs adverse effects

liver toxicity, bone marrow toxicity, agranulocytosis, leukopenia, thrombocytopenia, nephritis, enlarged thyroid gland

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18

antithyroid medications are pregnancy class

D (thyroidectomy is best option during pregnancy)

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19

antithyroid patient education

takes 2 weeks for symptom improvement, avoid sources of iodine (iodized salt, tofu, soy, seafood, breads), report s/s of liver and bone marrow toxicity (fever, sore throat, skin eruptions, bleeding/bruising)

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