Herpes Viruses, Pox Viruses, Human Papilloma Virus

Herpes virus properties

Double-stranded DNA
Enveloped

Herpes virus 1 transmission

Respiratory secretions & saliva

Herpes virus 2 transmission

Sexual contact
Mom to baby (perinatal infection)

Herpesvirus pathogenesis

Replicated in skin/mucous membrane of site of infection
Goes latent in sensory ganglion cells

HSV 1 Diseases

Gingivostomatitis
Herpes labialis (cold sores)
Keratoconjunctivitis
Herpetic whitlow
Encephalitis (temporal)
Keratitis

HSV 2 Diseases

Genital herpes
Neonatal herpes
Aseptic meningitis

HSV 8 Diseases

Kaposi's sarcoma

HSV 1 is ____ the waist HSV2 is ____ the waist

above, below

Epstein-Barr Virus properties

Viral capsid antigen

Epstein-Barr Virus transmission

Saliva (kissing)

Epstein-Barr Virus pathogenesis

Starts in oropharynx and spreads to the blood
Infects B lymphocytes

Epstein-Barr Virus clinical findings

Fever, sore throat, lymphadenopathy, spleenomegaly

Epstein-Barr Virus diseases

Infectious mono
Hairy leukoplakia

Human Papilloma Virus properties

Circular double-stranded DNA
Nonenveloped

Human Papilloma Virus transmission

Skin-to-skin contact

Human Papilloma Virus pathogenesis

Infect squamous epithetal cells and create a vacuole in them

Koilocytes are these vacuolated cells

Human Papilloma Virus clinical findings

Papillomas (benign tumors of squamous cells) aka warts

Human Papilloma Virus disease

Genital warts (condylomata acuminata)
Skin & plantar warts
Cancer: cervical, oropharyngeal, penal, anal

Poxviruses properties

Linear double-stranded DNA

Small pox transmission

Direct contact with skin lesions or fomites (inanimate objects)
Respiratory aerosol

Monekypox transmission

Direct contact with diseased body parts or bodily fluid

Molluscum contagoisum transmission

Close personal contact

Poxviruses pathogenesis

Enters the upper respiratory tract and then multiplies and spreads to nearby lymph nodes

Then spread via blood to other organs

Then re-enters the blood and spreads to the skin

Smallpox clinical findings

Rash which is worse on face and extremities

Monkeypox clinical findings

Rash that starts on face and spreads over entire body

Molluscum contagiosum clinical findings

Lesions with cup-shaped center

Poxviruses diseases

Smallpox
Monkeypox
Molluscum contagiosum