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What is the function of B-1 B cells?
B-1 B cells occupy and protect body cavities.
What is the role of B-2 B cells?
B-2 B cells make up the majority of B cells that survey and combat infections after becoming activated in secondary lymphoid tissues.
Where are marginal-zone B cells found, and what is their role?
Marginal-zone B cells are found in the spleen and protect against bloodborne pathogens.
Where does B-cell development occur in adult mice and humans?
In the bone marrow and spleen.
Why does the location of B-cell development change during fetal development?
Because the bone marrow is not present in the early embryo, and the location depends on the site of hematopoietic stem cell (HSC) production.