B cells can be divided into several subtypes & Fetal B-cell development

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5 Terms

1

What is the function of B-1 B cells?

B-1 B cells occupy and protect body cavities.

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2

What is the role of B-2 B cells?

B-2 B cells make up the majority of B cells that survey and combat infections after becoming activated in secondary lymphoid tissues.

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3

Where are marginal-zone B cells found, and what is their role?

Marginal-zone B cells are found in the spleen and protect against bloodborne pathogens.

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4

Where does B-cell development occur in adult mice and humans?

In the bone marrow and spleen.

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5

Why does the location of B-cell development change during fetal development?

Because the bone marrow is not present in the early embryo, and the location depends on the site of hematopoietic stem cell (HSC) production.

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