Beta lactum antiobiotics 1

Penicillins Mechanism of action ???

PBP transpidtedase

time killing dependent

List one Use of penicillin G , and is it IV or oral

Syphillis ( All stages ) , Its IV

TRYPNOMA PALLEDUM ( PAINLESS )

What is the Resistance Mechanism of MRSA

PBP 2a

Penicillin binding protein

Mec A gene ****** ( high yeild )

List Methicillin sensitive staphycocus aurus antibiotics

nafcillin , oxacillin , dicloxacillin

Amoxicillin , Ampcillin , are given in combination with what B-lactamase inhibitor

What are they used for ,

Almost always with Clavulante

Acute ootis media

Lower respiratory infections

Sinusitis

UTI ( in pregnancy🤰 and non complicated )

Community acquired pneumonia

Impetigo

Bacterial meningitis caused by

listeria menengitis is given what antibiotics

penicillin G with gentamicin

(Aminoglycoside , causes renal toxicity and Acute tubular necrosis )

Most effective penicillins vs pseudomonas and

what are they combined with

What are there uses

Pipercillin and ticacillin

Combined with Tazobactum or clavulanate

complicated UTI

• Presentation: A 7-year-old boy presents with sore throat, fever, and difficulty swallowing for three days.

• Examination reveals erythema and swelling of the tonsils with purulent exudate.

• What is your diagnosis.

• WHAT ANTIBIOTICS SHOULD BE GIVEN

Strepto throught

Antibiotics : penecillin V ( oral )

Acute ootis media is given what antibiotics

Amoxicillin + clavunate

Crackeles (lung sounds )

And s. Pneumonia

What are the antibiotics to choose

Ceftrixone (chephalosporin )+ azithromycin (microlide )

High Fever , Flank pain , DYSURIA , urine culture revels e.coli

What is the diagnosis and Antibiotics

Acute pylenephritis

Ceftriaxone

• Presentation: A 30-year-old male presents with dysuria and purulent discharge.
  Urine culture identifies Neisseria gonorrboeae.

Antibiotics to choose from

Ceftriaxone

Which cephalosporine is the best for MRSA

Ceftaroline 5th gen

Carbapenums include

Imipenum

meropenum

Doripenum

Imipenum (carbapenums ) is always given with what drug and for what reason

What are common side effects

Always taken with cilastatin *

To prevent renal degeneration 🫘****

*seizures

Used for Streptococcus

HIGH SIZURE RISK ⚡️

Meropenum uses

Used for menengitis 🧠, best CNS  penetration

Doripenum uses

Anti pseudomonas 🌱

What drug class is a last resort options for ESBL

(Extended spectrum- beta lactamase )producing bacteria and polymicrobial infections  , hospital acquired

Used for : sepsis - infections

Carbapenums

Monobactums is a class compromised of only 1 drug ,

What is that drug

What is its Meachnism of action

What is the spectrum and

Uses

Aztreonam       Targets PBP3

Used in : Gram negative (-) Aerobes 💨

Preferred in Penicillin allergy ***

Used for pseudomonas