prelim 5 - tablet defects

Partial separation of top or bottom crown (Defect)

Capping

Separation into 2 or more distinct layers (Defect)

Lamination

In concave tablets (Defect)

Cracking

Adhesion of material to die wall or face of the punch (Defect)

Sticking

Adhesion of material to the design embedded on the punch tip (Defect)

Picking

Removal of small portion of tablet edges (Defect)

Chipping

Two engravings on the surface (Defect)

Double impression

Uneven color distribution (Defect)

Mottling

Oily film or droplets of liquid (Defect)

Sweating

Markings are obscured (Defect)

Bridging

Removal of coating from the tablet surface (Defect)

Erosion

Craters appears exposing the tablet surface (Defect)

Cratering

Reduced adhesion and detachment of the film (Defect)

Blistering

Fading or dulling of the film (Defect)

Blooming

Whitish specks or haziness of the film (Defect)

Blushing

Two tablets stick together (Defect)

Twinning

Rough, non-glossy surface (Defect)

Orange peel

Film of the tablet flakes off, exposing the tablet surface (Defect)

Flaking

Caused by entrapment of air (Defect)

Blistering

Caused by high degree of attrition (Defect)

Chipping

Caused by insufficient drying or rate of coating solution application is too high (Defect)

Cratering

Caused by connection of the surface of LMW ingredients included in the coating formulation (Defect)

Picking

Caused by rapid drying (Defect)

Blooming

Caused by mixing problem or spray problem (Defect)

Orange peel

Remedy is allow more spraying time (Defect)

Blistering

Remedy is increase the film hardness by increasing MW of the polymer (Defect)

Chipping

Remedy is to decrease the drying air temperature (Defect)

Cratering

Remedy is not using hot air to dry the tablets at the end of the coating (Defect)

Picking

Remedy is extending time between the compactor of the sugar coating (Defect)

Blooming

Remedy is reducing air temperature (Defect)

Orange peel

Remedy is addition of alcohol and usage of finer spray nozzles (Defect)

Mottling

Remedy is increase the drying air temperature and decrease application rate (Defect)

Infilling )